1. Gene
  2. BAD - BCL2 associated agonist of cell death Gene

BAD - BCL2 associated agonist of cell death Gene

中文名称:BCL2 相关的细胞死亡激动因子

种属: Homo sapiens

同用名: BBC2; BCL2L8

基因 ID: 572 | 基因类型: protein coding

关于 BAD

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,269,828-64,284,704 (from NCBI)

This gene has 7 transcripts (splice variants) and 79 orthologues. Ubiquitous expression in colon (RPKM 20.0), fat (RPKM 18.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是 Bcl-2 家族的成员。已知 Bcl-2 家族成员是程序性细胞死亡的调节剂。该蛋白通过与 Bcl-xL (特大 B 细胞淋巴瘤) 和 Bcl-2 形成异二聚体并逆转其死亡抑制活性来正向调节细胞凋亡。该蛋白的促凋亡活性通过其磷酸化进行调节。发现蛋白激酶 Akt 和 MAP 激酶以及蛋白磷酸酶钙调神经磷酸酶参与该蛋白的调节。该基因的可变剪接导致编码相同亚型的两个转录物变体。[RefSeq 提供,2019 年 12 月]

The protein encoded by this gene is a member of the Bcl-2 Family. Bcl-2 Family members are known to be regulators of programmed cell death. This protein positively regulates cell Apoptosis by forming heterodimers with Bcl-xL (B-cell lymphoma-extra large) and Bcl-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases Akt and MAP kinase, as well as protein phosphatase Calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]

BAD 基因产物(2)

mRNA Protein Name
NM_004322.3 NP_004313.1 bcl2-associated agonist of cell death
NM_032989.3 NP_116784.1 bcl2-associated agonist of cell death
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: 通过直接分析推断
18402937 GOA
enables lipid binding IDA
IDA: 通过直接分析推断
19667065 GOA
enables phospholipid binding IMP
IMP: 通过突变表型推断
21081150 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9388232 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17270021 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
18387192 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
19667065 GOA
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
20810912 GOA
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in cellular response to nicotine IDA
IDA: 通过直接分析推断
18676776 GOA
involved in extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
18852119 GOA
involved in intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
18676776 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
18402937 GOA
involved in pore complex assembly IDA
IDA: 通过直接分析推断
19667065 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
9388232 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17289999 GOA
involved in positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
19593445 GOA
involved in positive regulation of proteolysis IDA
IDA: 通过直接分析推断
18387192 GOA
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
17289999 GOA
involved in regulation of mitochondrial membrane permeability IMP
IMP: 通过突变表型推断
20700721 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of BAD-BCL-2 complex IPI
IPI: 通过物理相互作用推断
9463381 GOA
located in cytosol IDA
IDA: 通过直接分析推断
20700721 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
20700721 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BAD 蛋白结构

Bcl-2_BAD

Bcl-2_BAD: Pro-apoptotic Bcl-2 protein, BAD (1 - 168)

  • 0
  • 100
  • 168 a.a.
蛋白主名 其他名称

bcl2-associated agonist of cell death

BCL-X/BCL-2 binding protein

BAD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BAD Q92934 CAPN1 Homo sapiens P07384 32814053
种属内
BAD Q92934 CAPN1 Homo sapiens P07384 32814053
种属内
BAD Q92934 CAPN1 Homo sapiens P07384 32814053
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817-1 20603619
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817-1 15131699
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817-1
Y2H
9388232
种属内
BAD Q92934 YWHAH Homo sapiens Q04917 31980649
种属内
BAD Q92934 YWHAZ Homo sapiens P63104 31980649
种属内
BAD Q92934 YWHAZ Homo sapiens P63104
SPR
19667065
种属内
BAD Q92934 YWHAZ Homo sapiens P63104
PLA
23397142
种属内
BAD Q92934 YWHAZ Homo sapiens P63104
Y2H
21988832
种属内
BAD Q92934 YWHAE Homo sapiens P62258 33961781
种属内
BAD Q92934 YWHAE Homo sapiens P62258 20936779
种属内
BAD Q92934 YWHAE Homo sapiens P62258 31980649
种属内
BAD Q92934 YWHAE Homo sapiens P62258 36931259
种属内
BAD Q92934 YWHAB Homo sapiens P31946
Y2H
21900206
种属内
BAD Q92934 YWHAB Homo sapiens P31946 31980649
种属内
BAD Q92934 YWHAG Homo sapiens P61981 31980649
种属内
BAD Q92934 YWHAG Homo sapiens P61981 20936779
种属内
BAD Q92934 YWHAQ Homo sapiens P27348 31980649
种属内
BAD Q92934 YWHAQ Homo sapiens P27348 21988832
种属内
BAD Q92934 SFN Homo sapiens P31947 31980649
种属内
BAD Q92934 SFN Homo sapiens P31947 20179209
种属内
BAD Q92934 SFN Homo sapiens P31947 16189514
种属内
BAD Q92934 SFN Homo sapiens P31947 33961781
种属内
BAD Q92934 BCL2L11 Homo sapiens O43521 19427863
种属内
BAD Q92934 BCL2L2 Homo sapiens Q92843
SPR
15694340
种属间
BAD Q92934 OPG035 vaccinia virus P17361 17485524
种属内
BAD Q92934 BCL2 Homo sapiens P10415 17446862
种属内
BAD Q92934 BCL2 Homo sapiens P10415 9388232
种属内
BAD Q92934 BCL2 Homo sapiens P10415 9463381
种属内
BAD Q92934 ACTN2 Homo sapiens P35609 32296183
种属内
BAD Q92934 ACTN2 Homo sapiens P35609 32296183
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 31980649
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 31515488
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 31467278
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 25416956
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817
SLC
31467278
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 29997244
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 32814053
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 37398436
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 31467278
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 19427857
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817 29997244
种属内
BAD Q92934 BCL2L1 Homo sapiens Q07817
PLA
25241761
种属内
BAD Q92934 BNIP3L Homo sapiens O60238 9973195
种属内
BAD Q92934 KRT31 Homo sapiens Q15323 32296183
种属内
BAD Q92934 KRT31 Homo sapiens Q15323 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

BAD 抗体

目录号 产品名 应用 反应物种
HY-P83354 Phospho-Bad (Ser112) Antibody (YA3099) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Transient Cerebral Ischemia

Transient Ischemic Attack

Transient Ischemic Attacks

Tia

Tia - Transient Ischaemic Attack

Transient Cerebral Ischaemia

Ischemic Attack, Transient

Intermittent Cerebral Ischemia

Tia - [Transient Ischaemic Attack]

Intermittent Cerebral Ischaemia

Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus BAD VGNC VGNC:102738
Bos taurus BAD VGNC VGNC:26404
Mus musculus BAD MGD MGI:1096330
Canis familiaris BAD VGNC VGNC:38362
Rattus norvegicus BAD RGD RGD:620103
Macaca mulatta BAD VGNC VGNC:70218
Macaca fascicularis BAD NCBI NCBI:102121921
Others BAD NCBI