1. Gene
  2. SRSF10 - serine and arginine rich splicing factor 10 Gene

SRSF10 - serine and arginine rich splicing factor 10 Gene

中文名称:富丝氨酸和精氨酸的剪接因子 10

种属: Homo sapiens

同用名: NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149

基因 ID: 10772 | 基因类型: protein coding

关于 SRSF10

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,964,347-23,980,327 (from NCBI)

This gene has 16 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues.

功能概要

该基因产物是丝氨酸-精氨酸 (SR) 蛋白家族的成员,参与组成型和受调控的 RNA 剪接。该家族成员的特征是 N 末端 RNP1 和 RNP2 基序,它们是结合 RNA 所必需的,以及多个 C 末端 SR/RS 重复序列,这在介导与其他细胞蛋白的结合中很重要。该蛋白与癌蛋白 TLS 相互作用,并消除 TLS 对腺病毒 E1A pre-mRNA 剪接的影响。该基因在 4 号、9 号、14 号、18 号和 20 号染色体上具有假基因。可变剪接导致多个转录变体。[RefSeq 提供,2014 年 7 月]

This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with Other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

SRSF10 基因产物(8)

mRNA Protein Name
NM_001191005.3 NP_001177934.1 serine/arginine-rich splicing factor 10 isoform 3
NM_001191006.3 NP_001177935.1 serine/arginine-rich splicing factor 10 isoform 4
NM_001191007.3 NP_001177936.1 serine/arginine-rich splicing factor 10 isoform 5
NM_001191009.3 NP_001177938.1 serine/arginine-rich splicing factor 10 isoform 6
NM_001300936.2 NP_001287865.1 serine/arginine-rich splicing factor 10 isoform 8
NM_001300937.2 NP_001287866.1 serine/arginine-rich splicing factor 10 isoform 9
NM_006625.6 NP_006616.1 serine/arginine-rich splicing factor 10 isoform 1
NM_054016.4 NP_473357.1 serine/arginine-rich splicing factor 10 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
26876937 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9774382 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA splicing, via transesterification reactions IDA
IDA: 通过直接分析推断
9774382 GOA
involved in mRNA splice site recognition IDA
IDA: 通过直接分析推断
9774382 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
9774382 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
11684676 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
26876937 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
26876937 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
11684676 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SRSF10 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 81)

  • 0
  • 100
  • 200
  • 262 a.a.
蛋白主名 其他名称

serine/arginine-rich splicing factor 10

40 kDa SR-repressor protein

SRSF10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SRSF10 O75494 CLK1 Homo sapiens P49759-3
Validated Y2H
32296183
种属内
SRSF10 O75494 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
SRSF10 O75494 YWHAG Homo sapiens P61981
CoIP
15324660
种属内
SRSF10 O75494 YWHAG Homo sapiens P61981
SLC
36931259
种属内
SRSF10 O75494 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
种属内
SRSF10 O75494 SFN Homo sapiens P31947
TAP
15778465
种属内
SRSF10 O75494 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
种属内
SRSF10 O75494 CLK3 Homo sapiens P49761
Validated Y2H
32296183
种属内
SRSF10 O75494 CLK3 Homo sapiens P49761
Y2H Array
32296183
种属内
SRSF10 O75494 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alexithymia
Alcoholic Ketoacidosis
Capillary Malformations, Congenital

Familial Multiple Nevi Flammei

Nevi Flammei, Familial Multiple

CMC

Port-Wine Stain

Capillary Malformations

Cmal

Familial Multiple Port-Wine Stains

Capillary Malformation

Capillary Malformations, Congenital, 1, Somatic, Mosaic

Congenital Capillary Malformations

Port-Wine Stain Familial Multiple

Hereditary Capillary Malformations

Capillary Malformations, Hereditary

Capillary Malformations, Congenital, Type 1, Somatic, Mosaic

Strawberry Nevus Of Skin

Naevus Flammeus

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SRSF10 MGD MGI:1333805
Bos taurus SRSF10 VGNC VGNC:35298
Rattus norvegicus SRSF10 RGD RGD:1311067
Macaca mulatta SRSF10 VGNC VGNC:106502
Felis catus SRSF10 VGNC VGNC:107641