CDC25B - cell division cycle 25B Gene

中文名称：细胞分裂周期 25B

种属: Homo sapiens

基因 ID: 994 | 基因类型: protein coding

关于 CDC25B

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,786,951-3,806,115 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues.

功能概要

CDC25B 是 CDC25 磷酸酶家族的成员。 CDC25B 通过去除两个磷酸基团激活细胞周期蛋白依赖性激酶 CDC2，它是进入有丝分裂所必需的。由于核定位和核输出信号，CDC25B 在细胞核和细胞质之间穿梭。该蛋白在细胞周期的 M 期和 G1 期处于核内，在 S 期和 G2 期移至细胞质。 CDC25B 具有致癌特性，但其在肿瘤形成中的作用尚未确定。该基因存在多个转录变体。[RefSeq 提供，2008 年 7 月]

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

CDC25B 基因产物(10)

mRNA	Protein	Name
NM_001287516.2	NP_001274445.1	M-phase inducer phosphatase 2 isoform 4
NM_001287517.2	NP_001274446.1	M-phase inducer phosphatase 2 isoform 5
NM_001287518.2	NP_001274447.1	M-phase inducer phosphatase 2 isoform 6
NM_001287519.2	NP_001274448.1	M-phase inducer phosphatase 2 isoform 7
NM_001287520.2	NP_001274449.1	M-phase inducer phosphatase 2 isoform 7
NM_001287522.2	NP_001274451.1	M-phase inducer phosphatase 2 isoform 8
NM_001287524.2	NP_001274453.1	M-phase inducer phosphatase 2 isoform 9
NM_004358.5	NP_004349.1	M-phase inducer phosphatase 2 isoform 2
NM_021872.4	NP_068658.1	M-phase inducer phosphatase 2 isoform 3
NM_021873.4	NP_068659.1	M-phase inducer phosphatase 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphoprotein phosphatase activity	IDA IDA: 通过直接分析推断	20360007	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7644510	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	12400006	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	20360007	GOA
involved in positive regulation of cytokinesis	IMP IMP: 通过突变表型推断	17332740	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	17332740	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	17332740	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	15908796	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	15908796	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC25B 蛋白结构

M-inducer_phosp

Rhodanese

0
100
200
300
400
500
580 a.a.

蛋白主名

其他名称

M-phase inducer phosphatase 2

CDC25 homolog B

CDC25B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	CoIP	16672277
种属内	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Y2H	10713667
种属内	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Affinity Chrom	10713667
种属内	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
种属内	CDC25B	P30305	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	26496610
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Y2H	10713667
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Affinity Chrom	10713667
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Pull Down	12766774
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	28514442
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Pull Down	12764136
种属内	CDC25B	P30305	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	26496610
种属内	CDC25B	P30305	PSME3	Homo sapiens	P61289	Validated Y2H	32296183
种属内	CDC25B	P30305	PSME3	Homo sapiens	P61289	Y2H Array	32296183
种属内	CDC25B	P30305	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
种属内	CDC25B	P30305	YWHAE	Homo sapiens	P62258	Affinity Chrom	12871587
种属内	CDC25B	P30305	YWHAE	Homo sapiens	P62258	Y2H	7644510
种属内	CDC25B	P30305	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Affinity Chrom	12871587
种属内	CDC25B	P30305	YWHAB	Homo sapiens	P31946	CoIP	16672277
种属内	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	26496610
种属内	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Y2H	7644510
种属内	CDC25B	P30305	YWHAB	Homo sapiens	P31946	Y2H	10713667
种属内	CDC25B	P30305	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	26496610

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100034	NSC 663284	Inhibitor	99.29%	否
HY-108543	NSC 95397		≥99.0%	否
HY-135457	JMS-053		≥98.0%	否
HY-112776A	BN82002 hydrochloride	Inhibitor	99.36%	否
HY-151986	FOXM1-IN-1	Inhibitor	99.54%	否
HY-128769	M2N12	Inhibitor	98.19%	否
HY-132578	M5N36	Inhibitor	98.05%	否
HY-137175A	CDC25B-IN-2	Inhibitor	97.02%	否
HY-126246	CDC25B-IN-1	Inhibitor	98.09%	否
HY-121065	BN-82685	Inhibitor	99.05%	否
HY-112776	BN82002	Inhibitor	/	否
HY-118529	JUN-1111	Inhibitor	98.57%	否
HY-135564B	(Rac)-RK-682	Inhibitor	/	否
HY-RS02292	CDC25B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W024644	Hydroxyethylthio Vitamine K3		≥97.0%	否
HY-N12177	Cryptosporioptide A	Inhibitor	/	否
HY-W102931	6,7-Dichloroquinoline-5,8-dione	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CDC25B	MGD	MGI:99701
Macaca mulatta	CDC25B	VGNC	VGNC:70795
Felis catus	CDC25B	VGNC	VGNC:60650
Bos taurus	CDC25B	VGNC	VGNC:27063
Rattus norvegicus	CDC25B	RGD	RGD:621500
Canis familiaris	CDC25B	VGNC	VGNC:38990

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