2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. 6,7-Dichloroquinoline-5,8-dione

6,7-Dichloroquinoline-5,8-dione (compound DA3002) 是一种有效的 CDC25B2 抑制剂，IC50 值为 4.6 µM。6,7-Dichloroquinoline-5,8-dione 具有用于癌症研究的潜力。

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6,7-Dichloroquinoline-5,8-dione Chemical Structure

6,7-Dichloroquinoline-5,8-dione Chemical Structure

CAS No. : 6541-19-1

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6,7-Dichloroquinoline-5,8-dione 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent CDC25B2 inhibitor with an IC50 value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer[1].

IC50 & Target

IC50: 4.6 µM (CDC25B2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C32 IC50
22.72 μM
Compound: 1
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
CEM-SS CC50
1 μM
Compound: 81047
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
HEK-293T CC50
17 μM
Compound: 81047
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
HFF-1 IC50
15.66 μM
Compound: 1
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
[PMID: 28006669]
HL-60 IC50
31.8 μM
Compound: 7a
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 20363637]
MCF7 IC50
22.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
MDA-MB-231 IC50
24.96 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
MT4 CC50
2 μM
Compound: 81047
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
Neutrophil IC50
1.3 μM
Compound: 7a
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
[PMID: 20363637]
SNB-19 IC50
26.1 μM
Compound: 1
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
T-cell IC50
32.9 μM
Compound: 7a
Antiproliferative activity against human T cells after 48 hrs by MTT assay
Antiproliferative activity against human T cells after 48 hrs by MTT assay
[PMID: 20363637]
分子量

228.03

Formula

C9H3Cl2NO2
CAS 号
性状

固体

颜色

Light green to green

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

6,7-Dichloroquinoline-5,8-dione 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

6,7-Dichloroquinoline-5,8-dione6541-19-1Phosphatasedual specificity protein phosphatase Cdc25cancerInhibitorinhibitorinhibit

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