HNRNPD - heterogeneous nuclear ribonucleoprotein D Gene

中文名称：异质性核糖核蛋白 D

种属: Homo sapiens

同用名: P37; AUF1; AUF1A; HNRPD; hnRNPD0

关于 HNRNPD

功能概要

该基因属于普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族。 hnRNPs 是核酸结合蛋白，它们与异质核 RNA (hnRNA) 复合。这些蛋白质与细胞核中的前体 mRNA 相关，并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。虽然所有的 hnRNP 都存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。由该基因编码的蛋白质具有两个重复的与 RNA 结合的准 RRM 结构域。它定位于细胞核和细胞质。该蛋白质与 mRNA 稳定性的调节有关。该基因的可变剪接导致四种转录本变体。[RefSeq 提供，2008 年 7 月]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]