PLK3 - polo like kinase 3 Gene

中文名称：马球样激酶 3

种属: Homo sapiens

同用名: CNK; FNK; PRK; PLK-3

基因 ID: 1263 | 基因类型: protein coding

关于 PLK3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,800,377-44,805,990 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), gall bladder (RPKM 12.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质是高度保守的丝氨酸/苏氨酸激酶类 polo 激酶家族的成员。该家族成员的特征在于氨基末端激酶结构域和羧基末端二分马球盒结构域，其作为底物结合基序和细胞定位信号。 Polo 样激酶是细胞周期进程的重要调节因子。该基因还与应激反应和双链断裂修复有关。在人类细胞系中，据报道这种蛋白质以微管依赖性方式与中心体结合，在有丝分裂过程中，该蛋白质定位于有丝分裂器。激酶缺陷型突变体的表达导致细胞形态异常，这是由微管动力学变化和有丝分裂停滞随后细胞凋亡引起的。[RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by Apoptosis. [provided by RefSeq, Sep 2015]

PLK3 基因产物(3)

mRNA	Protein	Name
NM_004073.4	NP_004064.2	serine/threonine-protein kinase PLK3
XM_047444455.1	XP_047300411.1	serine/threonine-protein kinase PLK3 isoform X1
XM_047444463.1	XP_047300419.1	serine/threonine-protein kinase PLK3 isoform X2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables p53 binding	IDA IDA: 通过直接分析推断	11447225	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14968113	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	11447225	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	19490146	GOA
involved in DNA damage response	IMP IMP: 通过突变表型推断	16481012	GOA
involved in G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	17264206	GOA
involved in Golgi disassembly	IDA IDA: 通过直接分析推断	14980500	GOA
involved in cytoplasmic microtubule organization	IMP IMP: 通过突变表型推断	20951827	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	19490146	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19490146	GOA
involved in positive regulation of chaperone-mediated autophagy	IDA IDA: 通过直接分析推断	27344333	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: 通过突变表型推断	20951827	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia	IDA IDA: 通过直接分析推断	20889502	GOA
involved in regulation of cell division	IDA IDA: 通过直接分析推断	20951827	GOA
involved in regulation of cytokinesis	IMP IMP: 通过突变表型推断	16478733	GOA
involved in response to osmotic stress	IDA IDA: 通过直接分析推断	21098032	GOA
involved in response to radiation	IDA IDA: 通过直接分析推断	21376736	GOA
involved in response to reactive oxygen species	IDA IDA: 通过直接分析推断	11447225	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi stack	IDA IDA: 通过直接分析推断	14980500	GOA
located in centrosome	IDA IDA: 通过直接分析推断	16478733	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19490146	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	17264206	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19490146	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLK3 蛋白结构

Pkinase

POLO_box

0
100
200
300
400
500
600
646 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase PLK3

FGF-inducible kinase	cytokine-inducible serine/threonine-protein kinase
proliferation-related kinase

PLK3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PLK3	Q9H4B4	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	PLK3	Q9H4B4	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	PLK3	Q9H4B4	VRK1	Homo sapiens	Q99986	Confocal	19103756
Intra	PLK3	Q9H4B4	VRK1	Homo sapiens	Q99986	Pull Down	19103756
Intra	PLK3	Q9H4B4	VRK1	Homo sapiens	Q99986	Protein Kinase Assay	19103756
Intra	PLK3	Q9H4B4	LSM5	Homo sapiens	Q9Y4Y9	Y2H Prey Pooling	32296183
Intra	PLK3	Q9H4B4	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	PLK3	Q9H4B4	LSM5	Homo sapiens	Q9Y4Y9	Y2H Array	32296183
Intra	PLK3	Q9H4B4	RNF141	Homo sapiens	Q8WVD5	Y2H Prey Pooling	32296183
Intra	PLK3	Q9H4B4	RNF141	Homo sapiens	Q8WVD5	Y2H Array	32296183
Intra	PLK3	Q9H4B4	RAD52	Homo sapiens	P43351	Y2H Array	32296183
Intra	PLK3	Q9H4B4	RAD52	Homo sapiens	P43351	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells	HPS1
Delta Storage Pool Disease	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Hermansky-Pudlak Syndrome, Type 1	Platelet Storage Pool Deficiency

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6	Parkinson Disease 6
PARK6	Parkinson Disease 6, Early Onset
Parkinson'S Disease 6	Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1
Parkinson Disease 6, Early-Onset	Autosomal Recessive Early-Onset Parkinson'S Disease 6
Early-Onset Parkinson Disease 6	Autosomal Recessive Early-Onset Parkinson Disease Type 6
Parkinson Disease 6 Early-Onset	Parkinson Disease 6 Late-Onset Susceptibility To
Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1	Parkinsonism Young Adult Onset
Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Anal Squamous Cell Carcinoma

Epidermoid Anal Carcinoma

Carcinoma Of Anal Margin

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-12137	Volasertib	Inhibitor	99.41%	是
HY-12137A	Volasertib trihydrochloride	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-50698	BI 2536	Inhibitor	99.95%	Phase 2
HY-147298	Plogosertib	Inhibitor	99.95%	Phase 2
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.19%	Phase 1
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10197	Wortmannin	Inhibitor	99.86%	否
HY-100789	ON1231320	Inhibitor	99.24%	否
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	否
HY-11003	GW843682X	Inhibitor	99.89%	否
HY-108597	TC-S 7005	Inhibitor	99.56%	否
HY-15158	SBE13 Hydrochloride	Inhibitor	99.66%	否
HY-12134	Poloxin	Inhibitor	98.01%	否
HY-110002	LFM-A13	Inhibitor	99.65%	否
HY-15158A	SBE13	Inhibitor	/	否
HY-149100	PLK1-IN-6	Inhibitor	/	否
HY-115589	YLT-11	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PLK3	RGD	RGD:62039
Felis catus	PLK3	VGNC	VGNC:64245
Macaca mulatta	PLK3	VGNC	VGNC:76092
Canis familiaris	PLK3	VGNC	VGNC:44697
Mus musculus	PLK3	MGD	MGI:109604
Bos taurus	PLK3	VGNC	VGNC:33035
Others	PLK3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PLK3 - polo like kinase 3 Gene

关于 PLK3

功能概要

PLK3 基因产物(3)

PLK3 蛋白结构

PLK3 蛋白互作信息

关联疾病

直系同源

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PLK3 - polo like kinase 3 Gene

关于 PLK3

功能概要

PLK3 基因产物(3)

PLK3 蛋白结构

PLK3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

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Z