2. Gene
  3. CDC6 - cell division cycle 6 Gene

CDC6 - cell division cycle 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞分裂周期 6

种属: Homo sapiens

同用名: CDC18L; HsCDC6; MGORS5; HsCDC18

基因 ID: 990 | 基因类型: protein coding

关于 CDC6

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,287,879-40,304,657 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues.

功能概要

该基因编码的蛋白质与酿酒酵母 Cdc6 高度相似，后者是启动 DNA 复制所必需的蛋白质。这种蛋白质在 DNA 复制的早期阶段起调节作用。它在细胞周期 G1 期间定位于细胞核，但在 S 期开始时易位至细胞质。这种蛋白质在细胞周期中的亚细胞易位是通过 Cdks 的磷酸化来调节的。据报道，该蛋白质的转录通过涉及 E2F 蛋白质的转录控制机制响应促有丝分裂信号而受到调节。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

CDC6 基因产物(1)

mRNA Protein Name
NM_001254.4 NP_001245.1 cell division control protein 6 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase binding IPI
IPI: 通过物理相互作用推断
21041660 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14672932 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of chromosome segregation IDA
IDA: 通过直接分析推断
21041660 GOA
involved in positive regulation of cytokinesis IMP
IMP: 通过突变表型推断
21041660 GOA
involved in regulation of mitotic metaphase/anaphase transition IMP
IMP: 通过突变表型推断
21041660 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
NOT located in nucleolus IDA
IDA: 通过直接分析推断
21383955 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21041660 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
21041660 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
21041660 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC6 蛋白结构

AAA_22

AAA_22: AAA domain (194 - 316)

Cdc6_C

Cdc6_C: CDC6, C terminal winged helix domain (466 - 545)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 560 a.a.
蛋白主名 其他名称

cell division control protein 6 homolog

CDC6 cell division cycle 6 homolog

CDC6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC6 Q99741 CDK1 Homo sapiens P06493
Anti Bait CoIP
21041660
种属内
CDC6 Q99741 CDK1 Homo sapiens P06493
Anti Tag CoIP
21041660
种属内
CDC6 Q99741 CDT1 Homo sapiens Q9H211
Protein Array
15232106
种属内
CDC6 Q99741 PLK1 Homo sapiens P53350
Pull Down
21041660
种属内
CDC6 Q99741 PLK1 Homo sapiens P53350
Protein Kinase Assay
21041660
种属内
CDC6 Q99741 PLK1 Homo sapiens P53350
Anti Bait CoIP
21041660
种属间: 跨种属相互作用 种属内: 同种属相互作用

CDC6 抗体

目录号 产品名 应用 反应物种
HY-P81295 Phospho-CDC6 (Ser106) Antibody (YA1016) WB Human, Rat
HY-P81295A Phospho-CDC6 (Ser54) Antibody (YA1017) WB, ICC/IF Human
HY-P82881 CDC6 Antibody (YA2626) WB, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Cervical Intraepithelial Neoplasia

CIN
Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02308 CDC6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CDC6 MGD MGI:1345150
Macaca mulatta CDC6 VGNC VGNC:70802
Rattus norvegicus CDC6 RGD RGD:1309157
Felis catus CDC6 VGNC VGNC:60664
Bos taurus CDC6 VGNC VGNC:27081
Canis familiaris CDC6 VGNC VGNC:39009
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z