CDT1 - chromatin licensing and DNA replication factor 1 Gene

中文名称：染色质许可和 DNA 复制因子 1

种属: Homo sapiens

同用名: DUP; RIS2

基因 ID: 81620 | 基因类型: protein coding

关于 CDT1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,803,789-88,809,258 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues.

功能概要

该基因编码的蛋白质参与了 DNA 复制所必需的复制前复合物的形成。编码的蛋白质可以结合孪蛋白，从而防止复制，并可能起到防止这种蛋白质在不适当的起点开始复制的作用。细胞周期蛋白 A 依赖性激酶对该蛋白质的磷酸化导致蛋白质降解。[RefSeq 提供，2011 年 3 月]

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

CDT1 基因产物(1)

mRNA	Protein	Name
NM_030928.4	NP_112190.2	DNA replication factor Cdt1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	11125146	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11125146	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA replication checkpoint signaling	IDA IDA: 通过直接分析推断	14672932	GOA
involved in DNA replication preinitiation complex assembly	IDA IDA: 通过直接分析推断	11125146	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: 通过突变表型推断	22581055	GOA
involved in negative regulation of DNA-templated DNA replication	IDA IDA: 通过直接分析推断	19906994	GOA
involved in negative regulation of cell cycle	IDA IDA: 通过直接分析推断	19906994	GOA
involved in positive regulation of DNA replication	IMP IMP: 通过突变表型推断	26842564	GOA
involved in positive regulation of DNA-templated DNA replication	IDA IDA: 通过直接分析推断	11125146	GOA
involved in positive regulation of chromatin binding	IDA IDA: 通过直接分析推断	11125146	GOA
involved in regulation of DNA-templated DNA replication initiation	IDA IDA: 通过直接分析推断	11125146	GOA
involved in response to sorbitol	IDA IDA: 通过直接分析推断	21856198	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in kinetochore	IDA IDA: 通过直接分析推断	22581055	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11125146	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDT1 蛋白结构

CDT1

0
100
200
300
400
500
546 a.a.

蛋白主名

其他名称

DNA replication factor Cdt1

Double parked, Drosophila, homolog of

CDT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDT1	Q9H211	PCNA	Homo sapiens	P12004	Pull Down	16482215
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Peptide Array	15232106
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Pull Down	11125146
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	BFG-2H	27107012
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Pull Down	19906994
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	CoIP	11125146
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Pull Down	16482215
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	X-Ray Diffraction	19906994
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	SAXS	19906994
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Y2H	22581055
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	GMS	19906994
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	Anti Tag CoIP	21543332
种属内	CDT1	Q9H211	GMNN	Homo sapiens	O75496	SPR	19906994
种属内	CDT1	Q9H211	CDC6	Homo sapiens	Q99741	Pull Down	14672932
种属内	CDT1	Q9H211	MCM6	Homo sapiens	Q14566	Anti Tag CoIP	26496610
种属内	CDT1	Q9H211	MCM6	Homo sapiens	Q14566	NMR	20202939
种属内	CDT1	Q9H211	NDC80	Homo sapiens	O14777	Pull Down	22581055
种属内	CDT1	Q9H211	NDC80	Homo sapiens	O14777	Anti Bait CoIP	22581055
种属内	CDT1	Q9H211	NDC80	Homo sapiens	O14777	Y2H	22581055

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Meier-Gorlin Syndrome 4

MGORS4

Meier-Gorlin Syndrome, Type 4

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Genitourinary Tract Anomalies

Microtia

Congenital Small Ears

Hypoplasia Of Ear

Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02427	CDT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CDT1	VGNC	VGNC:27158
Canis familiaris	CDT1	VGNC	VGNC:39083
Macaca mulatta	CDT1	VGNC	VGNC:71092
Felis catus	CDT1	VGNC	VGNC:60721
Rattus norvegicus	CDT1	RGD	RGD:1309211
Mus musculus	CDT1	MGD	MGI:1914427

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CDT1 - chromatin licensing and DNA replication factor 1 Gene

关于 CDT1

功能概要

CDT1 基因产物(1)

CDT1 蛋白结构

CDT1 蛋白互作信息

关联疾病

直系同源

热门区域

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CDT1 - chromatin licensing and DNA replication factor 1 Gene

关于 CDT1

功能概要

CDT1 基因产物(1)

CDT1 蛋白结构

CDT1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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