2. Gene
  3. GMNN - geminin DNA replication inhibitor Gene

GMNN - geminin DNA replication inhibitor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：孪蛋白 DNA 复制抑制因子

种属: Homo sapiens

同用名: Gem; MGORS6

基因 ID: 51053 | 基因类型: protein coding

关于 GMNN

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,774,937-24,786,099 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 5.6) and 25 other tissues.

功能概要

该基因编码一种在细胞周期调节中起关键作用的蛋白质。编码的蛋白质通过与 DNA 复制因子 Cdt1 结合来抑制 DNA 复制，从而阻止微型染色体维持蛋白掺入预复制复合物中。编码的蛋白质在细胞周期的 S 和 G2 期表达，并在中期-后期转变期间被后期促进复合物降解。该基因表达增加可能在多种恶性肿瘤中发挥作用，包括结肠癌、直肠癌和乳腺癌。已观察到该基因的可变剪接转录本变体，该基因的两个假基因位于 16 号染色体的短臂上。[RefSeq 提供，2011 年 10 月]

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast Cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

GMNN 基因产物(4)

mRNA Protein Name
NM_001251989.2 NP_001238918.1 geminin
NM_001251990.2 NP_001238919.1 geminin
NM_001251991.1 NP_001238920.1 geminin
NM_015895.5 NP_056979.1 geminin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
11125146 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
16924111 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11125146 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication preinitiation complex assembly IDA
IDA: 通过直接分析推断
11125146 GOA
involved in negative regulation of DNA replication IDA
IDA: 通过直接分析推断
9635433 GOA
involved in negative regulation of DNA-templated DNA replication IDA
IDA: 通过直接分析推断
11125146 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16924111 GOA
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
9635433 GOA
involved in positive regulation of chromatin binding IDA
IDA: 通过直接分析推断
11125146 GOA
involved in regulation of DNA replication IMP
IMP: 通过突变表型推断
17234884 GOA
involved in regulation of DNA-templated DNA replication initiation IDA
IDA: 通过直接分析推断
24064211 GOA
involved in regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
21543332 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21543332 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21543332 GOA
part of transcription repressor complex IPI
IPI: 通过物理相互作用推断
22615398 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GMNN 蛋白结构

Geminin

Geminin: Geminin (1 - 190)

  • 0
  • 100
  • 209 a.a.
蛋白主名 其他名称

geminin

GMNN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GMNN O75496 ZNF250 Homo sapiens P15622-3
Validated Y2H
32296183
种属内
GMNN O75496 CCDC146 Homo sapiens Q8IYE0-2
Validated Y2H
25416956
种属内
GMNN O75496 CCDC146 Homo sapiens Q8IYE0-2
Y2H Array
25416956
种属内
GMNN O75496 CCDC146 Homo sapiens Q8IYE0-2
Y2H Prey Pooling
25416956
种属内
GMNN O75496 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
种属内
GMNN O75496 PTPN11 Homo sapiens Q06124-2
Validated Y2H
32296183
种属内
GMNN O75496 HOXC9 Homo sapiens P31274
ITC
22615398
种属内
GMNN O75496 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
种属内
GMNN O75496 SAPCD2 Homo sapiens Q86UD0
Validated Y2H
32296183
种属内
GMNN O75496 MCIDAS Homo sapiens D6RGH6
Anti Bait CoIP
21543332
种属内
GMNN O75496 MCIDAS Homo sapiens D6RGH6
Anti Tag CoIP
33961781
种属内
GMNN O75496 MCIDAS Homo sapiens D6RGH6
IF
21543332
种属内
GMNN O75496 MCIDAS Homo sapiens D6RGH6
Anti Tag CoIP
28514442
种属内
GMNN O75496 MCIDAS Homo sapiens D6RGH6
Anti Tag CoIP
21543332
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
CoIP
11125146
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Anti Tag CoIP
17318181
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Pull Down
14993212
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
FRET
17318181
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Anti Tag CoIP
26496610
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Validated Y2H
27107012
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
SPR
21543332
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Anti Tag CoIP
33961781
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Anti Tag CoIP
28514442
种属内
GMNN O75496 CDT1 Homo sapiens Q9H211
Protein Array
15232106
种属内
GMNN O75496 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
种属内
GMNN O75496 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
GMNN O75496 ZNF439 Homo sapiens Q8NDP4
Y2H Prey Pooling
25416956
种属内
GMNN O75496 ZNF439 Homo sapiens Q8NDP4
Validated Y2H
32296183
种属内
GMNN O75496 ZNF439 Homo sapiens Q8NDP4
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

GMNN 抗体

目录号 产品名 应用 反应物种
HY-P81394 Geminin Antibody (YA1139) IHC-P Human

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 6

MGORS6
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma
Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Melanoacanthoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05523 GMNN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GMNN VGNC VGNC:41291
Bos taurus GMNN VGNC VGNC:29439
Rattus norvegicus GMNN RGD RGD:1308137
Mus musculus GMNN MGD MGI:1927344
Felis catus GMNN VGNC VGNC:62609
Macaca mulatta GMNN VGNC VGNC:72954
Others GMNN NCBI
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