2. Gene
  3. CDC7 - cell division cycle 7 Gene

CDC7 - cell division cycle 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞分裂周期 7

种属: Homo sapiens

同用名: Hsk1; CDC7L1; HsCDC7; huCDC7

基因 ID: 8317 | 基因类型: protein coding

关于 CDC7

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,500,851-91,525,764 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 12 paralogues. Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues.

功能概要

该基因编码一种具有激酶活性的细胞分裂周期蛋白，该蛋白对 G1/S 转换至关重要。当细胞分裂发生时，酵母同系物对于启动 DNA 复制也是必不可少的。该基因产物的过度表达可能与某些肿瘤的肿瘤转化有关。已检测到编码相同蛋白质的多个可变剪接转录物变体。[RefSeq 提供，2008 年 8 月]

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

CDC7 基因产物(3)

mRNA Protein Name
NM_001134419.2 NP_001127891.1 cell division cycle 7-related protein kinase
NM_001134420.2 NP_001127892.1 cell division cycle 7-related protein kinase
NM_003503.4 NP_003494.1 cell division cycle 7-related protein kinase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase activity IDA
IDA: 通过直接分析推断
9250678 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12065429 GOA
enables protein kinase activity IMP
IMP: 通过突变表型推断
12065429 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell cycle phase transition IMP
IMP: 通过突变表型推断
17102137 GOA
involved in positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
15668232 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17102137 GOA
involved in positive regulation of nuclear cell cycle DNA replication IMP
IMP: 通过突变表型推断
15668232 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9250678 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9250678 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC7 蛋白结构

Pkinase

Pkinase: Protein kinase domain (58 - 204)

Pkinase

Pkinase: Protein kinase domain (365 - 569)

  • 0
  • 100
  • 200
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  • 500
  • 574 a.a.
蛋白主名 其他名称

cell division cycle 7-related protein kinase

CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1

CDC7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC7 O00311 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
种属内
CDC7 O00311 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 FXR1 Homo sapiens P51114-2
Validated Y2H
32296183
种属内
CDC7 O00311 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
种属内
CDC7 O00311 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
种属内
CDC7 O00311 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
种属内
CDC7 O00311 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
种属内
CDC7 O00311 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
种属内
CDC7 O00311 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
种属内
CDC7 O00311 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
种属内
CDC7 O00311 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
种属内
CDC7 O00311 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
种属内
CDC7 O00311 ZBTB10 Homo sapiens Q96DT7-3
Validated Y2H
32296183
种属内
CDC7 O00311 ZBTB10 Homo sapiens Q96DT7-3
Y2H Array
32296183
种属内
CDC7 O00311 ZBTB10 Homo sapiens Q96DT7-3
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
种属内
CDC7 O00311 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
种属内
CDC7 O00311 WUGSC:H_DJ0726N20.gs.b Homo sapiens Q9Y6T4
Validated Y2H
32296183
种属内
CDC7 O00311 IKZF4 Homo sapiens Q9H2S9
Validated Y2H
32296183
种属内
CDC7 O00311 IKZF4 Homo sapiens Q9H2S9
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 IKZF4 Homo sapiens Q9H2S9
Y2H Array
32296183
种属内
CDC7 O00311 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
CDC7 O00311 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
CDC7 O00311 ZBTB8B Homo sapiens Q8NAP8
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 ZBTB8B Homo sapiens Q8NAP8
Validated Y2H
32296183
种属内
CDC7 O00311 ZBTB8B Homo sapiens Q8NAP8
Y2H Array
32296183
种属内
CDC7 O00311 TSPY10 Homo sapiens P0CW01
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 TSPY10 Homo sapiens P0CW01
Validated Y2H
32296183
种属内
CDC7 O00311 TSPY10 Homo sapiens P0CW01
Y2H Array
32296183
种属内
CDC7 O00311 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
种属内
CDC7 O00311 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
种属内
CDC7 O00311 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 SERTAD2 Homo sapiens Q14140
Validated Y2H
32296183
种属内
CDC7 O00311 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
种属内
CDC7 O00311 DBF4 Homo sapiens Q9UBU7
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 DBF4 Homo sapiens Q9UBU7
Validated Y2H
32296183
种属内
CDC7 O00311 DBF4 Homo sapiens Q9UBU7
Y2H Array
32296183
种属内
CDC7 O00311 DBF4 Homo sapiens Q9UBU7
GMS
16899510
种属内
CDC7 O00311 DBF4 Homo sapiens Q9UBU7
Y2H Array
31515488
种属内
CDC7 O00311 DBF4 Homo sapiens Q9UBU7
Pull Down
32707033
种属内
CDC7 O00311 STAM2 Homo sapiens O75886
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 STAM2 Homo sapiens O75886
Validated Y2H
32296183
种属内
CDC7 O00311 STAM2 Homo sapiens O75886
Y2H Array
32296183
种属内
CDC7 O00311 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
种属内
CDC7 O00311 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
种属内
CDC7 O00311 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
CDC7 O00311 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
CDC7 O00311 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
CDC7 O00311 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
种属内
CDC7 O00311 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
CDC7 O00311 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 TSNAXIP1 Homo sapiens Q2TAA8
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 TSNAXIP1 Homo sapiens Q2TAA8
Validated Y2H
32296183
种属内
CDC7 O00311 TSNAXIP1 Homo sapiens Q2TAA8
Y2H Array
32296183
种属内
CDC7 O00311 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
种属内
CDC7 O00311 TRIM27 Homo sapiens P14373
Y2H Array
32296183
种属内
CDC7 O00311 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
种属内
CDC7 O00311 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
种属内
CDC7 O00311 TRIM37 Homo sapiens O94972
Validated Y2H
32296183
种属内
CDC7 O00311 TRIM37 Homo sapiens O94972
Y2H Array
32296183
种属内
CDC7 O00311 TRIM37 Homo sapiens O94972
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
种属内
CDC7 O00311 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
种属内
CDC7 O00311 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
种属内
CDC7 O00311 GMEB2 Homo sapiens Q9UKD1
Y2H Prey Pooling
32296183
种属内
CDC7 O00311 GMEB2 Homo sapiens Q9UKD1
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-100888 Simurosertib Inhibitor 99.94% Phase 2
HY-143430A (S)-LY3177833 hydrate Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15260A XL413 monohydrochloride Inhibitor 99.72% 否
HY-13461A PHA-767491 hydrochloride 99.49% 否
HY-133028 CKI-7 free base Inhibitor 99.80% 否
HY-15260 XL413 Inhibitor 99.76% 否
HY-100023 LY3177833 Inhibitor 99.48% 否
HY-100888A (R)-Simurosertib Control 99.58% 否
HY-101523 Cdc7-IN-1 Inhibitor 99.77% 否
HY-130517 Cdc7-IN-5 Inhibitor 96.73% 否
HY-100023A LY3177833 monhydrate Inhibitor 99.76% 否
HY-148065 FMF-06-098-1 / 否
HY-13461 PHA-767491 Inhibitor 99.85% 否
HY-130516 Cdc7-IN-4 Inhibitor / 否
HY-130515 Cdc7-IN-3 Inhibitor / 否
HY-130519 Cdc7-IN-7 Inhibitor / 否
HY-117677 Cdc7-IN-21 Inhibitor / 否
HY-143377 Cdc7-IN-8 Inhibitor / 否
HY-143380 Cdc7-IN-9 Inhibitor / 否
HY-143385 Cdc7-IN-12 Inhibitor / 否
HY-143387 Cdc7-IN-13 Inhibitor / 否
HY-143389 Cdc7-IN-14 Inhibitor / 否
HY-143429 Cdc7-IN-15 Inhibitor / 否
HY-143430 (S)-LY3177833 Inhibitor / 否
HY-143431 Cdc7-IN-17 Inhibitor / 否
HY-143432 Cdc7-IN-18 Inhibitor / 否
HY-143432A (S)-Cdc7-IN-18 Inhibitor / 否
HY-143433 Cdc7-IN-19 Inhibitor / 否
HY-15260C XL413 hydrochloride Inhibitor / 否
HY-162007 PYRA-2 Inhibitor / 否
HY-163374 Cdc7-IN-20 Inhibitor / 否
HY-RS02309 CDC7 Human Pre-designed siRNA Set A / 否
HY-W011109 CKI-7 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CDC7 VGNC VGNC:80164
Mus musculus CDC7 MGD MGI:1309511
Canis familiaris CDC7 VGNC VGNC:39010
Macaca mulatta CDC7 VGNC VGNC:106340
Rattus norvegicus CDC7 RGD RGD:1308351
Bos taurus CDC7 VGNC VGNC:27082
Others CDC7 NCBI
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