ORC3 - origin recognition complex subunit 3 Gene

中文名称：起源识别复合亚基 3

种属: Homo sapiens

同用名: LAT; ORC3L; LATHEO

基因 ID: 23595 | 基因类型: protein coding

关于 ORC3

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,590,135-87,677,823 (from NCBI)

This gene has 7 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 9.4), adrenal (RPKM 6.1) and 25 other tissues.

功能概要

起源识别复合物 (ORC) 是一种高度保守的六亚基蛋白复合物，对于真核细胞中 DNA 复制的启动至关重要。对酵母的研究表明，ORC 与复制起点特异性结合，并作为组装其他起始因子 (如 Cdc6 和 Mcm 蛋白) 的平台。该基因编码的蛋白质是 ORC 复合体的一个亚基。对果蝇中相似基因的研究表明，这种蛋白质可能在神经元增殖和嗅觉记忆中发挥作用。已经报道了该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

ORC3 基因产物(3)

mRNA	Protein	Name
NM_001197259.2	NP_001184188.1	origin recognition complex subunit 3 isoform 3
NM_012381.4	NP_036513.2	origin recognition complex subunit 3 isoform 2
NM_181837.3	NP_862820.1	origin recognition complex subunit 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15232106	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA replication initiation	IDA IDA: 通过直接分析推断	16549788	GOA
involved in regulation of DNA replication	IDA IDA: 通过直接分析推断	31160578	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	31160578	GOA
part of nuclear origin of replication recognition complex	IDA IDA: 通过直接分析推断	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: 通过物理相互作用推断	16549788	GOA
part of origin recognition complex	IDA IDA: 通过直接分析推断	17716973	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ORC3 蛋白结构

ORC3_N

0
200
400
600
711 a.a.

蛋白主名

其他名称

origin recognition complex subunit 3

homolog of latheo, Drosophila

ORC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ORC3	Q9UBD5	ORC6	Homo sapiens	Q9Y5N6	Anti Bait CoIP	17716973
种属内	ORC3	Q9UBD5	ORC1	Homo sapiens	Q13415	Anti Bait CoIP	17716973
种属内	ORC3	Q9UBD5	ORC4	Homo sapiens	O43929	Anti Bait CoIP	17716973
种属内	ORC3	Q9UBD5	ORC5	Homo sapiens	O43913	Protein Array	15232106
种属内	ORC3	Q9UBD5	ORC5	Homo sapiens	O43913	Anti Bait CoIP	17716973
种属内	ORC3	Q9UBD5	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	17716973

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type	VEODS
Mrxsveod	Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type
X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09827	ORC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ORC3	VGNC	VGNC:32448
Mus musculus	ORC3	MGD	MGI:1354944
Canis familiaris	ORC3	VGNC	VGNC:44142
Rattus norvegicus	ORC3	RGD	RGD:1308457
Felis catus	ORC3	VGNC	VGNC:68650
Macaca mulatta	ORC3	VGNC	VGNC:75715
Others	ORC3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ORC3 - origin recognition complex subunit 3 Gene

关于 ORC3

功能概要

ORC3 基因产物(3)

ORC3 蛋白结构

ORC3 蛋白互作信息

关联疾病

直系同源

热门区域

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ORC3 - origin recognition complex subunit 3 Gene

关于 ORC3

功能概要

ORC3 基因产物(3)

ORC3 蛋白结构

ORC3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z