2. Gene
  3. ORC6 - origin recognition complex subunit 6 Gene

ORC6 - origin recognition complex subunit 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：起源识别复合亚基 6

种属: Homo sapiens

同用名: ORC6L

基因 ID: 23594 | 基因类型: protein coding

关于 ORC6

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,689,659-46,698,394 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 6.8), bone marrow (RPKM 5.0) and 16 other tissues.

功能概要

起源识别复合物 (ORC) 是一种高度保守的六亚基蛋白复合物，对于真核细胞中 DNA 复制的启动至关重要。对酵母的研究表明，ORC 与复制起点特异性结合，并作为组装其他起始因子 (如 Cdc6 和 Mcm 蛋白) 的平台。该基因编码的蛋白质是 ORC 复合体的一个亚基。用小干扰 RNA 进行的基因沉默研究表明，这种蛋白质在协调染色体复制和分离与胞质分裂中起着重要作用。[RefSeq 提供，2010 年 10 月]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

ORC6 基因产物(1)

mRNA Protein Name
NM_014321.4 NP_055136.1 origin recognition complex subunit 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15232106 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication initiation IDA
IDA: 通过直接分析推断
16549788 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of nuclear origin of replication recognition complex IPI
IPI: 通过物理相互作用推断
16549788 GOA
part of origin recognition complex IDA
IDA: 通过直接分析推断
17716973 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ORC6 蛋白结构

ORC6

ORC6: Origin recognition complex subunit 6 (ORC6) (8 - 94)

  • 0
  • 100
  • 200
  • 252 a.a.
蛋白主名 其他名称

origin recognition complex subunit 6

ORC6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Y2H Array
31515488
Intra ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Validated Y2H
25416956
Intra ORC6 Q9Y5N6 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra ORC6 Q9Y5N6 ORC4 Homo sapiens O43929
Protein Array
15232106
Intra ORC6 Q9Y5N6 ORC3 Homo sapiens Q9UBD5
Pull Down
17716973
Intra ORC6 Q9Y5N6 ORC3 Homo sapiens Q9UBD5
Protein Array
15232106
Intra ORC6 Q9Y5N6 SPAG5 Homo sapiens Q96R06
Y2H Prey Pooling
25416956
Intra ORC6 Q9Y5N6 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra ORC6 Q9Y5N6 HMGA1 Homo sapiens P17096
Anti Bait CoIP
18234858
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Microtia

Congenital Small Ears

Hypoplasia Of Ear
Genitourinary Tract Anomalies
Isolated Growth Hormone Deficiency

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Pituitary Dwarfism

Dwarfism, Pituitary

Isolated Somatotropin Deficiency

Isolated Congenital Growth Hormone Deficiency

Familial Isolated Growth Hormone Deficiency

Ighd

Dwarfism, Growth Hormone Deficiency

Growth Hormone Deficiency Dwarfism

Isolated Gh Deficiency

Isolated Hgh Deficiency

Isolated Human Growth Hormone Deficiency

Isolated Somatotropin Deficiency Disorder

Dwarfism Pituitary
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09830 ORC6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ORC6 VGNC VGNC:32451
Mus musculus ORC6 MGD MGI:1929285
Macaca mulatta ORC6 VGNC VGNC:75637
Felis catus ORC6 VGNC VGNC:63973
Canis familiaris ORC6 VGNC VGNC:44145
Rattus norvegicus ORC6 RGD RGD:1311437
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