HMGA1 - high mobility group AT-hook 1 Gene

中文名称：高机动性组 AT-hook 1

种属: Homo sapiens

同用名: HMG-R; HMGIY; HMGA1A

基因 ID: 3159 | 基因类型: protein coding

关于 HMGA1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,236,873-34,246,231 (from NCBI)

This gene has 9 transcripts (splice variants), 103 orthologues and is associated with 33 phenotypes. Broad expression in lymph node (RPKM 58.3), bone marrow (RPKM 57.3) and 23 other tissues.

功能概要

该基因编码一种染色质相关蛋白，参与基因转录调控、逆转录病毒整合到染色体中以及癌细胞的转移进程。编码的蛋白质优先结合双链 DNA 中富含 AT 区域的小沟。已发现该基因编码不同异构体的多个转录变体。已在多条染色体上鉴定出该基因的假基因。[RefSeq 提供，2016 年 1 月]

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of Cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

HMGA1 基因产物(12)

mRNA	Protein	Name
NM_001319077.2	NP_001306006.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001319078.2	NP_001306007.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319079.2	NP_001306008.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319080.2	NP_001306009.1	high mobility group protein HMG-I/HMG-Y isoform c
NM_001319081.2	NP_001306010.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319082.2	NP_001306011.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_002131.4	NP_002122.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145899.3	NP_665906.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_145901.3	NP_665908.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_145902.3	NP_665909.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145903.3	NP_665910.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145905.3	NP_665912.1	high mobility group protein HMG-I/HMG-Y isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: 通过直接分析推断	19465398	GOA
enables DNA binding	EXP EXP: 通过实验结果推断	9253416	GOA
enables DNA binding	IDA IDA: 通过直接分析推断	11069991	GOA
enables DNA binding, bending	EXP EXP: 通过实验结果推断	22615915	GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: 通过直接分析推断	19465398	GOA
enables RNA binding	IPI IPI: 通过物理相互作用推断	21087998	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9253416	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	16157300	GOA
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: 通过直接分析推断	9253416	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	11069991	GOA
enables molecular function activator activity	IMP IMP: 通过突变表型推断	21087998	GOA
enables nuclear receptor coactivator activity	IMP IMP: 通过突变表型推断	10428834	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: 通过直接分析推断	10428834	GOA
enables nuclear retinoid X receptor binding	IDA IDA: 通过直接分析推断	10428834	GOA
enables peroxisome proliferator activated receptor binding	IDA IDA: 通过直接分析推断	10428834	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9809067	GOA
enables transcription coactivator activity	EXP EXP: 通过实验结果推断	9253416	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	10428834	GOA
enables transcription coregulator binding	IDA IDA: 通过直接分析推断	10428834	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in base-excision repair	IDA IDA: 通过直接分析推断	19465398	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	16901784	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	16901784	GOA
involved in oncogene-induced cell senescence	IDA IDA: 通过直接分析推断	16901784	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	10428834	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	16901784	GOA
located in senescence-associated heterochromatin focus	IDA IDA: 通过直接分析推断	16901784	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HMGA1 蛋白结构

AT_hook

0
100
107 a.a.

蛋白主名

其他名称

high mobility group protein HMG-I/HMG-Y

high mobility group protein A1

HMGA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	HMGA1	P17096	H1-3	Homo sapiens	P16402	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2BC21	Homo sapiens	Q16778	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	33961781
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Crosslink	30021884
Intra	HMGA1	P17096	H4C16	Homo sapiens	P62805	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	Pull Down	18234858
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	Anti Bait CoIP	18234858
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	BiFC	18234858

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Lipomatosis, Multiple

Lipoma	Familial Multiple Lipomatosis
Lipomatosis, Familial Multiple	Benign Lipomatous Tumor
Lipomatous Neoplasm	Multiple Lipomatosis
Fml	Lipo
Benign Tumor Of Adipose Tissue	Lipomatous Tumor
Tumor Of Adipose Tissue	Neoplasms, Adipose Tissue
Lipomas

Pelvic Lipomatosis

Excess Of Mature Unencapsulated Fatty Tissue In The Pelvis

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Leiomyoma, Uterine

Uterine Leiomyoma	Uterine Fibroid
Uterine Fibroids	Plexiform Leiomyoma
UL	Leiomyoma Of Corpus Uteri
Uterus Fibroma

Breast Fibroadenoma

Fibroadenoma	Fibroadenoma Of Breast
Juvenile Fibroadenoma Of Breast	Cellular Fibroadenoma
Complex Fibroadenoma Of Breast	Juvenile Fibroadenoma
Fibroadenoma Nos	Fibroadenoma Unspecified Site

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06230	HMGA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HMGA1	RGD	RGD:628699
Bos taurus	HMGA1	VGNC	VGNC:29874
Mus musculus	HMGA1	MGD	MGI:96160
Canis familiaris	HMGA1	VGNC	VGNC:41709
Macaca mulatta	HMGA1	VGNC	VGNC:81076

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HMGA1 - high mobility group AT-hook 1 Gene

关于 HMGA1

功能概要

HMGA1 基因产物(12)

HMGA1 蛋白结构

HMGA1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

HMGA1 - high mobility group AT-hook 1 Gene

关于 HMGA1

功能概要

HMGA1 基因产物(12)

HMGA1 蛋白结构

HMGA1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z