ORC4 - origin recognition complex subunit 4 Gene

中文名称：起源识别复合亚基 4

种属: Homo sapiens

同用名: ORC4L; ORC4P

基因 ID: 5000 | 基因类型: protein coding

关于 ORC4

Cytogenetic location: 2q23.1 Genomic coordinates (GRCh38): 2:147,930,396-148,021,551 (from NCBI)

This gene has 16 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues.

功能概要

起源识别复合物 (ORC) 是一种高度保守的六亚基蛋白复合物，对于真核细胞中 DNA 复制的启动至关重要。对酵母的研究表明，ORC 与复制起点特异性结合，并作为组装其他起始因子 (如 Cdc6 和 Mcm 蛋白) 的平台。该基因编码 ORC 复合体的一个亚基。已经报道了该基因的几种可变剪接的转录物变体，其中一些编码相同的蛋白质。[RefSeq 提供，2010 年 10 月]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]

ORC4 基因产物(8)

mRNA	Protein	Name
NM_001190879.3	NP_001177808.1	origin recognition complex subunit 4 isoform 1
NM_001190881.3	NP_001177810.1	origin recognition complex subunit 4 isoform 2
NM_001190882.3	NP_001177811.1	origin recognition complex subunit 4 isoform 3
NM_001374270.1	NP_001361199.1	origin recognition complex subunit 4 isoform 1
NM_001374272.1	NP_001361201.1	origin recognition complex subunit 4 isoform 2
NM_002552.5	NP_002543.2	origin recognition complex subunit 4 isoform 1
NM_181741.4	NP_859525.1	origin recognition complex subunit 4 isoform 1
NM_181742.4	NP_859526.1	origin recognition complex subunit 4 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA replication origin binding	IMP IMP: 通过突变表型推断	9353276	GOA
enables nucleotide binding	IDA IDA: 通过直接分析推断	9353276	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15232106	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA replication initiation	IDA IDA: 通过直接分析推断	16549788	GOA
involved in DNA replication initiation	IMP IMP: 通过突变表型推断	9353276	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with chromosome, telomeric region	IDA IDA: 通过直接分析推断	24270157	GOA
part of nuclear origin of replication recognition complex	IDA IDA: 通过直接分析推断	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: 通过物理相互作用推断	16549788	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9353276	GOA
part of origin recognition complex	IDA IDA: 通过直接分析推断	17716973	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ORC4 蛋白结构

AAA_16

ORC4_C

0
100
200
300
400
436 a.a.

蛋白主名

其他名称

origin recognition complex subunit 4

origin recognition complex, subunit 4 homolog

ORC4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ORC4	O43929	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	33961781
种属内	ORC4	O43929	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	28514442
种属内	ORC4	O43929	ORC6	Homo sapiens	Q9Y5N6	BiFC	18234858
种属内	ORC4	O43929	ORC3	Homo sapiens	Q9UBD5	Anti Bait CoIP	17716973
种属内	ORC4	O43929	ORC3	Homo sapiens	Q9UBD5	Protein Array	15232106
种属内	ORC4	O43929	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	17716973
种属内	ORC4	O43929	TCF4	Homo sapiens	P15884	Y2H Array	25416956
种属内	ORC4	O43929	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
种属内	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Validated Y2H	25416956
种属内	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Y2H Array	25416956
种属内	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Mbd5 Haploinsufficiency

2q23.1 Microdeletion Syndrome	2q23.1 Microduplication Syndrome
Del(2)(Q23.1)	Monosomy 2q23.1
Pseudo-Angelman Syndrome	Mbd5 Associated Neurodevelopmental Disorder
Chromosome 2q23.1 Microdeletion Syndrome	Mbd5-Associated Neurodevelopmental Disorder
Mand	Dup(2)(Q23.1)
Trisomy 2q23.1

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Microtia

Congenital Small Ears

Hypoplasia Of Ear

Genitourinary Tract Anomalies

Isolated Growth Hormone Deficiency

Congenital Ighd	Congenital Isolated Gh Deficiency
Congenital Isolated Growth Hormone Deficiency	Non-Acquired Isolated Growth Hormone Deficiency
Pituitary Dwarfism	Dwarfism, Pituitary
Isolated Somatotropin Deficiency	Isolated Congenital Growth Hormone Deficiency
Familial Isolated Growth Hormone Deficiency	Ighd
Dwarfism, Growth Hormone Deficiency	Growth Hormone Deficiency Dwarfism
Isolated Gh Deficiency	Isolated Hgh Deficiency
Isolated Human Growth Hormone Deficiency	Isolated Somatotropin Deficiency Disorder
Dwarfism Pituitary

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Nemaline Myopathy 2

NEM2	Nemaline Myopathy 2, Autosomal Recessive
Nemaline Myopathy, Type 2	Neb-Related Nemaline Myopathy
Myopathy, Nemaline, Type 2

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09828	ORC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ORC4	VGNC	VGNC:44143
Macaca mulatta	ORC4	VGNC	VGNC:75716
Felis catus	ORC4	VGNC	VGNC:68651
Mus musculus	ORC4	MGD	MGI:1347043
Rattus norvegicus	ORC4	RGD	RGD:735212
Bos taurus	ORC4	VGNC	VGNC:32449

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ORC4 - origin recognition complex subunit 4 Gene

关于 ORC4

功能概要

ORC4 基因产物(8)

ORC4 蛋白结构

ORC4 蛋白互作信息

关联疾病

直系同源

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ORC4 - origin recognition complex subunit 4 Gene

关于 ORC4

功能概要

ORC4 基因产物(8)

ORC4 蛋白结构

ORC4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z