2. Gene
  3. ORC1 - origin recognition complex subunit 1 Gene

ORC1 - origin recognition complex subunit 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：起源识别复合亚基 1

种属: Homo sapiens

同用名: ORC1L; PARC1; HSORC1

基因 ID: 4998 | 基因类型: protein coding

关于 ORC1

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,372,829-52,409,503 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 7.3), lymph node (RPKM 2.5) and 10 other tissues.

功能概要

起源识别复合物 (ORC) 是一种高度保守的六亚基蛋白复合物，对于真核细胞中 DNA 复制的启动至关重要。对酵母的研究表明，ORC 与复制起点特异性结合，并作为组装其他起始因子 (如 Cdc6 和 Mcm 蛋白) 的平台。该基因编码的蛋白质是 ORC 复合体的最大亚基。虽然其他 ORC 亚基在整个细胞周期中都是稳定的，但这种蛋白质的水平在细胞周期中会发生变化，这已被证明在 DNA 复制开始后由泛素介导的蛋白水解控制。发现这种蛋白质在有丝分裂过程中被选择性磷酸化。据报道，它还与 MYST 组蛋白乙酰转移酶 2 (MyST2/HBO1) 相互作用，后者是一种参与控制转录沉默的蛋白质。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 6 月]

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST Histone Acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

ORC1 基因产物(3)

mRNA Protein Name
NM_001190818.2 NP_001177747.1 origin recognition complex subunit 1 isoform 1
NM_001190819.2 NP_001177748.1 origin recognition complex subunit 1 isoform 2
NM_004153.4 NP_004144.2 origin recognition complex subunit 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11931757 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication initiation IDA
IDA: 通过直接分析推断
16549788 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
24270157 GOA
part of nuclear origin of replication recognition complex IDA
IDA: 通过直接分析推断
20932478 GOA
part of nuclear origin of replication recognition complex IPI
IPI: 通过物理相互作用推断
16549788 GOA
part of origin recognition complex IDA
IDA: 通过直接分析推断
17716973 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ORC1 蛋白结构

BAH

BAH: BAH domain (46 - 166)

AAA

AAA: ATPase family associated with various cellular activities (AAA) (530 - 672)

Cdc6_C

Cdc6_C: CDC6, C terminal winged helix domain (778 - 858)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 861 a.a.
蛋白主名 其他名称

origin recognition complex subunit 1

origin recognition complex, subunit 1 homolog

ORC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ORC1 Q13415 ORC3 Homo sapiens Q9UBD5
Pull Down
17716973
Intra ORC1 Q13415 ORC3 Homo sapiens Q9UBD5
Protein Array
15232106
Intra ORC1 Q13415 ORC3 Homo sapiens Q9UBD5
Anti Tag CoIP
16549788
Intra ORC1 Q13415 ORC3 Homo sapiens Q9UBD5
Anti Tag CoIP
22398447
Intra ORC1 Q13415 ORC3 Homo sapiens Q9UBD5
Anti Tag CoIP
17716973
Intra ORC1 Q13415 ORC3 Homo sapiens Q9UBD5
Density Sedimentation
16549788
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Density Sedimentation
16549788
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Anti Tag CoIP
22398447
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Anti Tag CoIP
17716973
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Protein Array
15232106
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Anti Tag CoIP
16549788
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Pull Down
17716973
Intra ORC1 Q13415 ORC5 Homo sapiens O43913
Anti Tag CoIP
26496610
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Anti Tag CoIP
16549788
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
CoIP
11931757
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Anti Tag CoIP
26496610
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Pull Down
17716973
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Density Sedimentation
16549788
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Anti Tag CoIP
17716973
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Protein Array
15232106
Intra ORC1 Q13415 ORC2 Homo sapiens Q13416
Anti Tag CoIP
22398447
Intra ORC1 Q13415 SKP2 Homo sapiens Q13309
Pull Down
11931757
Intra ORC1 Q13415 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra ORC1 Q13415 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra ORC1 Q13415 TERF2 Homo sapiens Q15554
Pull Down
16799465
Cross ORC1 Q13415 EBNA1 Epstein-Barr virus P03211
Pull Down
18946490
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Microtia

Congenital Small Ears

Hypoplasia Of Ear
Genitourinary Tract Anomalies
Humeroradial Synostosis

Humero-Radial Fusion

Humero-Radial Synostosis

Ramer Ladda Syndrome
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09825 ORC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ORC1 MGD MGI:1328337
Rattus norvegicus ORC1 RGD RGD:631435
Felis catus ORC1 VGNC VGNC:68648
Canis familiaris ORC1 VGNC VGNC:44140
Bos taurus ORC1 VGNC VGNC:32446
Macaca mulatta ORC1 VGNC VGNC:106463
Others ORC1 NCBI
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