HLTF - helicase like transcription factor Gene

中文名称：解旋酶样转录因子

种属: Homo sapiens

同用名: ZBU1; HLTF1; RNF80; HIP116; SNF2L3; HIP116A; SMARCA3

基因 ID: 6596 | 基因类型: protein coding

关于 HLTF

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:149,030,063-149,086,533 (from NCBI)

This gene has 9 transcripts (splice variants), 184 orthologues and 30 paralogues. Broad expression in testis (RPKM 29.4), adrenal (RPKM 14.1) and 25 other tissues.

功能概要

该基因编码 SWI/SNF 家族的一个成员。该家族的成员具有解旋酶和 ATP 酶活性，被认为通过改变这些基因周围的染色质结构来调节某些基因的转录。编码的蛋白质包含环指 DNA 结合基序。已发现该基因编码相同蛋白质的两个转录变体。然而，与全长蛋白质相比，使用替代翻译起始位点会产生在 N 端被截短的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

HLTF 基因产物(8)

mRNA	Protein	Name
NM_001318934.2	NP_001305863.1	helicase-like transcription factor isoform 2
NM_001318935.2	NP_001305864.1	helicase-like transcription factor isoform 1
NM_003071.4	NP_003062.2	helicase-like transcription factor isoform 1
NM_139048.3	NP_620636.1	helicase-like transcription factor isoform 1
NM_001318934.2	NP_001305863.1	helicase-like transcription factor isoform 2
NM_001318935.2	NP_001305864.1	helicase-like transcription factor isoform 1
NM_003071.4	NP_003062.2	helicase-like transcription factor isoform 1
NM_139048.3	NP_620636.1	helicase-like transcription factor isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10391891	GOA
enables ubiquitin protein ligase activity	EXP EXP: 通过实验结果推断	18316726	GOA
enables ubiquitin protein ligase binding	IDA IDA: 通过直接分析推断	25023518	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase II transcription regulator complex	EXP EXP: 通过实验结果推断	23415230	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLTF 蛋白结构

HIRAN

SNF2_N

zf-RING_2

Helicase_C

0
200
400
600
800
1009 a.a.

蛋白主名

其他名称

helicase-like transcription factor

DNA-binding protein/plasminogen activator inhibitor-1 regulator

HLTF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HLTF	Q14527	UBE2N	Homo sapiens	P61088	Anti Tag CoIP	18719106
种属内	HLTF	Q14527	UBE2N	Homo sapiens	P61088	Anti Tag CoIP	18316726
种属内	HLTF	Q14527	UBE2N	Homo sapiens	P61088	Pull Down	18316726
种属内	HLTF	Q14527	RAD18	Homo sapiens	Q9NS91	Pull Down	18316726
种属内	HLTF	Q14527	RAD18	Homo sapiens	Q9NS91	Anti Tag CoIP	18316726
种属内	HLTF	Q14527	PCNA	Homo sapiens	P12004	Anti Tag CoIP	18316726
种属内	HLTF	Q14527	S100A10	Homo sapiens	P60903	Pull Down	23415230

种属间: 跨种属相互作用 种属内: 同种属相互作用

HLTF 抗体

目录号	产品名	应用	反应物种
HY-P82341	HLTF Antibody (YA2086)	WB, IHC-P, ICC/IF	Human, Rat

关联疾病

疾病名称

别名

Schimke Immunoosseous Dysplasia

Schimke Immuno-Osseous Dysplasia	SIOD
Immunoosseous Dysplasia, Schimke Type	Schimke Syndrome
Immunoosseous Dysplasia Schimke Type	Spondyloepiphyseal Dysplasia - Nephrotic Syndrome
Spondyloepiphyseal Dysplasia Nephrotic Syndrome	Spondyloepiphyseal Dysplasia-Nephrotic Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06220	HLTF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HLTF	RGD	RGD:1309031
Mus musculus	HLTF	MGD	MGI:1196437
Macaca mulatta	HLTF	VGNC	VGNC:73383
Bos taurus	HLTF	VGNC	VGNC:50276
Felis catus	HLTF	VGNC	VGNC:62822
Canis familiaris	HLTF	VGNC	VGNC:50301
Others	HLTF	NCBI

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