2. Gene
  3. CXXC1 - CXXC finger protein 1 Gene

CXXC1 - CXXC finger protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CXXC 指蛋白 1

种属: Homo sapiens

同用名: CFP1; CGBP; SPP1; PCCX1; PHF18; hCGBP; ZCGPC1; HsT2645; 2410002I16Rik; 5830420C16Rik

基因 ID: 30827 | 基因类型: protein coding

关于 CXXC1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:50,282,347-50,287,692 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.4), lymph node (RPKM 14.4) and 25 other tissues.

功能概要

该基因编码的蛋白质可作为转录激活因子，通过其 CXXC 结构域特异性结合非甲基化 CpG 基序。该蛋白质是 SETD1 复合物的组成部分，调节基因表达，对脊椎动物发育至关重要。[RefSeq 提供，2015 年 9 月]

This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

CXXC1 基因产物(2)

mRNA Protein Name
NM_001101654.2 NP_001095124.1 CXXC-type zinc finger protein 1 isoform 1
NM_014593.4 NP_055408.2 CXXC-type zinc finger protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17998332 GOA
enables unmethylated CpG binding IDA
IDA: 通过直接分析推断
10688657 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10688657 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10688657 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Set1C/COMPASS complex IDA
IDA: 通过直接分析推断
17998332 GOA
part of Set1C/COMPASS complex IPI
IPI: 通过物理相互作用推断
23508102 GOA
part of histone methyltransferase complex IDA
IDA: 通过直接分析推断
17355966 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10688657 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CXXC1 蛋白结构

PHD

PHD: PHD-finger (28 - 76)

zf-CXXC

zf-CXXC: CXXC zinc finger domain (163 - 208)

zf-CpG_bind_C

zf-CpG_bind_C: CpG binding protein zinc finger C terminal domain (400 - 636)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
蛋白主名 其他名称

CXXC-type zinc finger protein 1

CXXC finger 1 (PHD domain)

CXXC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CXXC1 Q9P0U4 TP53 Homo sapiens P04637
Anti Bait CoIP
23870121
Intra CXXC1 Q9P0U4 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
25416956
Intra CXXC1 Q9P0U4 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Tag CoIP
23870121
Intra CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Bait CoIP
23870121
Intra CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Tag CoIP
26496610
Intra CXXC1 Q9P0U4 RBBP5 Homo sapiens Q15291
Anti Tag CoIP
33961781
Intra CXXC1 Q9P0U4 PTEN Homo sapiens P60484
Anti Tag CoIP
21653829
Intra CXXC1 Q9P0U4 PTEN Homo sapiens P60484
Y2H Pooling
21653829
Intra CXXC1 Q9P0U4 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra CXXC1 Q9P0U4 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gait Apraxia
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03413 CXXC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CXXC1 VGNC VGNC:61304
Macaca mulatta CXXC1 VGNC VGNC:71517
Mus musculus CXXC1 MGD MGI:1921572
Rattus norvegicus CXXC1 RGD RGD:1310755
Bos taurus CXXC1 VGNC VGNC:27859
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