1. Gene
  2. TBC1D15 - TBC1 domain family member 15 Gene

TBC1D15 - TBC1 domain family member 15 Gene

中文名称:TBC1 域家族成员 15

种属: Homo sapiens

同用名: RAB7-GAP

基因 ID: 64786 | 基因类型: protein coding

关于 TBC1D15

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,839,759-71,924,313 (from NCBI)

This gene has 17 transcripts (splice variants), 218 orthologues and 45 paralogues. Ubiquitous expression in thyroid (RPKM 10.9), adrenal (RPKM 9.8) and 25 other tissues.

功能概要

该基因编码脑 GTP 酶激活蛋白超家族中 Ras 样蛋白的一个成员,它们共享一个保守的 Tre-2/Bub2/Cdc16 结构域。编码的蛋白质与大脑 5A 中的 Ras 样蛋白质相互作用,可能作为细胞内运输的调节剂发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供,2009 年 4 月]

This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

TBC1D15 基因产物(10)

mRNA Protein Name
NM_001146213.3 NP_001139685.2 TBC1 domain family member 15 isoform 3
NM_001146214.3 NP_001139686.2 TBC1 domain family member 15 isoform 2
NM_001385848.1 NP_001372777.1 TBC1 domain family member 15 isoform 4
NM_001385849.1 NP_001372778.1 TBC1 domain family member 15 isoform 5
NM_001385850.1 NP_001372779.1 TBC1 domain family member 15 isoform 6
NM_001385851.1 NP_001372780.1 TBC1 domain family member 15 isoform 7
NM_001385852.1 NP_001372781.1 TBC1 domain family member 15 isoform 8
NM_001385853.1 NP_001372782.1 TBC1 domain family member 15 isoform 9
NM_001385854.1 NP_001372783.1 TBC1 domain family member 15 isoform 10
NM_022771.6 NP_073608.4 TBC1 domain family member 15 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20562859 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in regulation of cilium assembly IMP
IMP: 通过突变表型推断
17646400 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TBC1D15 蛋白结构

DUF3548

DUF3548: Domain of unknown function (DUF3548) (8 - 220)

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (350 - 578)

  • 0
  • 200
  • 400
  • 600
  • 691 a.a.
蛋白主名 其他名称

TBC1 domain family member 15

GAP for RAB7

TBC1D15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TBC1D15 Q8TC07 CEP63 Homo sapiens Q96MT8-3 32296183
种属内
TBC1D15 Q8TC07 CEP63 Homo sapiens Q96MT8-3 32296183
种属内
TBC1D15 Q8TC07 CEP63 Homo sapiens Q96MT8-3 32296183
种属内
TBC1D15 Q8TC07 MAP1LC3B Homo sapiens Q9GZQ8 20562859
种属内
TBC1D15 Q8TC07 TAX1BP1 Homo sapiens Q86VP1 32296183
种属内
TBC1D15 Q8TC07 TAX1BP1 Homo sapiens Q86VP1 32296183
种属内
TBC1D15 Q8TC07 GABARAP Homo sapiens O95166 20562859
种属内
TBC1D15 Q8TC07 GABARAPL2 Homo sapiens P60520 20562859
种属内
TBC1D15 Q8TC07 CEP63 Homo sapiens Q96MT8 25416956
种属内
TBC1D15 Q8TC07 CEP63 Homo sapiens Q96MT8
Y2H
21516116
种属内
TBC1D15 Q8TC07 CEP63 Homo sapiens Q96MT8 25416956
种属内
TBC1D15 Q8TC07 GABARAPL1 Homo sapiens Q9H0R8 20562859
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 32814053
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 32296183
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 32296183
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 32814053
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 32814053
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 25416956
种属内
TBC1D15 Q8TC07 OPTN Homo sapiens Q96CV9 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Warburg Micro Syndrome 4

WARBM4

Micro Syndrome 4

Charcot-Marie-Tooth Disease, Axonal, Type 2b

Charcot-Marie-Tooth Disease Type 2b

CMT2B

Hmsn Iib

Hmsn2b

Charcot-Marie-Tooth Disease, Type 2b

Hereditary Motor And Sensory Neuropathy Iib

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2b

Charcot-Marie-Tooth Neuropathy Type 2b

Charcot-Marie-Tooth Disease, Autosomal Dominant, Type 2b

Charcot-Marie-Tooth Neuropathy, Type 2b

Hereditary Motor And Sensory Nueropathy Iib

Cmt 2b

Charcot Marie Tooth Disease Type 2b

Charcot-Marie-Tooth Disease, Neuronal, Type 2b

Hereditary Motor And Sensory Neuropathy 2 B

Peripheral Sensory Neuropathy, Autosomal Dominant

Charcot-Marie-Tooth Disease 2b

Charcot-Marie-Tooth Disease Axonal Type 2b

Charcot-Marie-Tooth Disease Neuronal Type 2b

Peripheral Sensory Neuropathy Autosomal Dominant

Psn

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TBC1D15 MGD MGI:1913937
Macaca mulatta TBC1D15 VGNC VGNC:78215
Felis catus TBC1D15 VGNC VGNC:65974
Rattus norvegicus TBC1D15 RGD RGD:1307920
Bos taurus TBC1D15 VGNC VGNC:35629
Canis familiaris TBC1D15 VGNC VGNC:47134