ZNF436 - zinc finger protein 436 Gene

中文名称：锌指蛋白 436

种属: Homo sapiens

同用名: ZNF; Zfp46

基因 ID: 80818 | 基因类型: protein coding

关于 ZNF436

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,359,448-23,369,836 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 205 orthologues and 174 paralogues. Ubiquitous expression in ovary (RPKM 11.7), brain (RPKM 9.2) and 25 other tissues.

功能概要

预测可启用 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 转录调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 对转录的负调控。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF436 基因产物(3)

mRNA	Protein	Name
NM_001077195.2	NP_001070663.1	zinc finger protein 436 isoform 1
NM_001370652.1	NP_001357581.1	zinc finger protein 436 isoform 2
NM_030634.3	NP_085137.1	zinc finger protein 436 isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23455924	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF436 蛋白结构

KRAB

zf-H2C2_2

0
100
200
300
400
470 a.a.

蛋白主名

其他名称

zinc finger protein 436

DNA-binding protein

ZNF436 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ZNF436	Q9C0F3	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	LMNA	Homo sapiens	P02545	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	LMNA	Homo sapiens	P02545	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	LMNA	Homo sapiens	P02545	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	ZNF436	Q9C0F3	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	ZNF436	Q9C0F3	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	ZNF436	Q9C0F3	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	ZNF436	Q9C0F3	ZNF580	Homo sapiens	Q9UK33	Validated Y2H	32296183
Intra	ZNF436	Q9C0F3	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 55

Combined Immunodeficiency Due To Gins1 Deficiency	IMD55
Cid Due To Gins1 Deficiency	Combined Immunodeficiency With Intrauterine Growth Retardation-Nk Cell Deficiency-Neutropenia
Combined Immunodeficiency With Intrauterine Growth Retardation-Natural Killer Cell Deficiency-Neutropenia

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Autosomal Dominant Intellectual Developmental Disorder 40

Autosomal Dominant Non-Syndromic Intellectual Disability 40	Autosomal Dominant Mental Retardation 40
Mrd40	Mental Retardation, Autosomal Dominant 40

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16140	ZNF436 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ZNF436	VGNC	VGNC:100194
Bos taurus	ZNF436	VGNC	VGNC:37275
Canis familiaris	ZNF436	VGNC	VGNC:48727
Rattus norvegicus	ZNF436	RGD	RGD:1310584
Mus musculus	ZNF436	MGD	MGI:99192

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