2. Gene
  3. PADI6 - peptidyl arginine deiminase 6 Gene

PADI6 - peptidyl arginine deiminase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肽基精氨酸脱亚胺酶 6

种属: Homo sapiens

同用名: hPADVI; PREMBL2

基因 ID: 353238 | 基因类型: protein coding

关于 PADI6

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,372,196-17,401,699 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 240 orthologues, 4 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

该基因编码肽基精氨酸脱亚胺酶家族的成员，该酶通过在钙离子存在下将精氨酸残基转化为瓜氨酸来催化蛋白质的翻译后脱亚胺。该家族成员具有不同的底物特异性和组织特异性表达模式。这种蛋白质可能在卵细胞骨架重组和早期胚胎发育中发挥作用。[RefSeq 提供，2012 年 9 月]

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

PADI6 基因产物(1)

mRNA Protein Name
NM_207421.4 NP_997304.3 protein-arginine deiminase type-6
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
27545678 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein-arginine deiminase type-6

peptidyl arginine deiminase, type VI

PADI6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PADI6 Q6TGC4 ZNF526 Homo sapiens Q8TF50
Validated Y2H
32296183
种属内
PADI6 Q6TGC4 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
种属内
PADI6 Q6TGC4 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
种属内
PADI6 Q6TGC4 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
种属内
PADI6 Q6TGC4 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
PADI6 Q6TGC4 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
PADI6 Q6TGC4 KLHL2 Homo sapiens O95198
Y2H Array
32296183
种属内
PADI6 Q6TGC4 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Preimplantation Embryonic Lethality 2

PREMBL2

Lethality, Embryonic, Preimplantation, Type 2
Infertility
Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism
Gestational Trophoblastic Neoplasm

Hydatidiform Mole

Molar Pregnancy

Gestational Trophoblastic Neoplasia

Gestational Trophoblastic Tumor

Gtn

Gestational Trophoblastic Disease

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole Benign

Trophoblastic Disease

Trophoblastic Disease Nos

Trophoblastic Disorder

Vesicular Mole Nos

Vesicular Mole

Hydatidiform Mole Nos
Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09964 PADI6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PADI6 VGNC VGNC:32549
Rattus norvegicus PADI6 RGD RGD:1560424
Macaca mulatta PADI6 VGNC VGNC:75657
Felis catus PADI6 VGNC VGNC:64023
Mus musculus PADI6 MGD MGI:2655198
Canis familiaris PADI6 VGNC VGNC:44238
Others PADI6 NCBI
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