1. Gene
  2. RRP8 - ribosomal RNA processing 8 Gene

RRP8 - ribosomal RNA processing 8 Gene

中文名称:核糖体 RNA 加工 8

种属: Homo sapiens

同用名: NML; KIAA0409

基因 ID: 23378 | 基因类型: protein coding

关于 RRP8

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,595,072-6,603,616 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues.

功能概要

启用甲基化组蛋白结合活性。参与多个过程,包括细胞对葡萄糖饥饿的反应; p53 类介质的内在凋亡信号通路;和基因表达的调控。位于几种细胞成分中,包括细胞质;核腔;和 rDNA 异染色质。染色质沉默复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]

RRP8 基因产物(1)

mRNA Protein Name
NM_015324.4 NP_056139.1 ribosomal RNA-processing protein 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylated histone binding IDA
IDA: 通过直接分析推断
18485871 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18485871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose starvation IMP
IMP: 通过突变表型推断
18485871 GOA
involved in energy homeostasis IMP
IMP: 通过突变表型推断
18485871 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
21471221 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
18485871 GOA
involved in negative regulation of cell cycle IMP
IMP: 通过突变表型推断
18485871 GOA
involved in rDNA heterochromatin formation IDA
IDA: 通过直接分析推断
18485871 GOA
involved in rDNA heterochromatin formation IMP
IMP: 通过突变表型推断
18485871 GOA
acts upstream of negative effect regulation of G1 to G0 transition IMP
IMP: 通过突变表型推断
21471221 GOA
involved in regulation of transcription by glucose IMP
IMP: 通过突变表型推断
18485871 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of chromatin silencing complex IDA
IDA: 通过直接分析推断
18485871 GOA
part of eNoSc complex IPI
IPI: 通过物理相互作用推断
18485871 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
18485871 GOA
located in rDNA heterochromatin IDA
IDA: 通过直接分析推断
18485871 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RRP8 蛋白结构

Methyltransf_8

Methyltransf_8: Hypothetical methyltransferase (238 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
蛋白主名 其他名称

ribosomal RNA-processing protein 8

RRP8 methyltransferase homolog

RRP8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RRP8 O43159 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
RRP8 O43159 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
RRP8 O43159 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
RRP8 O43159 SIRT1 Homo sapiens Q96EB6 18485871
种属内
RRP8 O43159 SIRT1 Homo sapiens Q96EB6 18485871
种属内
RRP8 O43159 SUV39H1 Homo sapiens O43463 18485871
种属内
RRP8 O43159 SUV39H1 Homo sapiens O43463 18485871
种属内
RRP8 O43159 DVL3 Homo sapiens Q92997 32296183
种属内
RRP8 O43159 DVL3 Homo sapiens Q92997 32296183
种属内
RRP8 O43159 DVL3 Homo sapiens Q92997 32296183
种属内
RRP8 O43159 PICK1 Homo sapiens Q9NRD5 32296183
种属内
RRP8 O43159 PICK1 Homo sapiens Q9NRD5 32296183
种属内
RRP8 O43159 PICK1 Homo sapiens Q9NRD5 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus RRP8 VGNC VGNC:64782
Rattus norvegicus RRP8 RGD RGD:1308302
Canis familiaris RRP8 VGNC VGNC:52288
Macaca mulatta RRP8 VGNC VGNC:77120
Bos taurus RRP8 VGNC VGNC:34171
Mus musculus RRP8 MGD MGI:1914251