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  2. RPRD1B - regulation of nuclear pre-mRNA domain containing 1B Gene

RPRD1B - regulation of nuclear pre-mRNA domain containing 1B Gene

中文名称:含核前 mRNA 结构域的调节 1B

种属: Homo sapiens

同用名: K-H; CREPT; NET60; C20orf77; Kub5-Hera; dJ1057B20.2

基因 ID: 58490 | 基因类型: protein coding

关于 RPRD1B

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,033,746-38,092,364 (from NCBI)

This gene has 9 transcripts (splice variants), 136 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 7.4), lymph node (RPKM 7.2) and 25 other tissues.

功能概要

启用 RNA 聚合酶 II 复合物结合活性和相同的蛋白质结合活性。参与细胞群增殖的正调控;调节细胞周期过程; RNA 聚合酶 II 对转录的调控。位于核质中。 RNA 聚合酶 II 的一部分,全酶。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]

RPRD1B 基因产物(1)

mRNA Protein Name
NM_021215.4 NP_067038.1 regulation of nuclear pre-mRNA domain-containing protein 1B

RPRD1B 蛋白结构

CTD_bind

CTD_bind: RNA polymerase II-binding domain. (56 - 117)

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  • 326 a.a.
蛋白主名 其他名称

regulation of nuclear pre-mRNA domain-containing protein 1B

Ku70-binding protein 5-Hera

RPRD1B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPRD1B Q9NQG5 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 STEEP1 Homo sapiens Q9H5V9
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 STEEP1 Homo sapiens Q9H5V9
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 RPRD1A Homo sapiens Q96P16
Anti Tag CoIP
33961781
种属内
RPRD1B Q9NQG5 RPRD1A Homo sapiens Q96P16
TAP
24981860
种属内
RPRD1B Q9NQG5 RPRD1A Homo sapiens Q96P16
Anti Tag CoIP
28514442
种属内
RPRD1B Q9NQG5 RPRD1A Homo sapiens Q96P16
Anti Tag CoIP
24997600
种属内
RPRD1B Q9NQG5 PIP4K2B Homo sapiens P78356-2
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 PIP4K2B Homo sapiens P78356-2
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 VAX1 Homo sapiens Q5SQQ9-2
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 VAX1 Homo sapiens Q5SQQ9-2
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 RPRD1A Homo sapiens Q96P16-3
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 RPRD1A Homo sapiens Q96P16-3
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 VPS37C Homo sapiens A5D8V6
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 BIN3 Homo sapiens Q9NQY0
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 BIN3 Homo sapiens Q9NQY0
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 BIN3 Homo sapiens Q9NQY0
Validated Y2H
32296183
种属内
RPRD1B Q9NQG5 RASSF3 Homo sapiens Q86WH2
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 RASSF3 Homo sapiens Q86WH2
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
TAP
24981860
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Anti Tag CoIP
33961781
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Anti Bait CoIP
22264791
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Anti Tag CoIP
28514442
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Pull Down
22264791
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Anti Bait CoIP
24997600
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Anti Tag CoIP
22264791
种属内
RPRD1B Q9NQG5 POLR2A Homo sapiens P24928
Anti Tag CoIP
24997600
种属内
RPRD1B Q9NQG5 PFDN6 Homo sapiens O15212
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 PFDN6 Homo sapiens O15212
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 HOXC4 Homo sapiens P09017
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 HOXC4 Homo sapiens P09017
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 RPAP2 Homo sapiens Q8IXW5
Anti Tag CoIP
24997600
种属内
RPRD1B Q9NQG5 RPAP2 Homo sapiens Q8IXW5
Anti Tag CoIP
33961781
种属内
RPRD1B Q9NQG5 RPAP2 Homo sapiens Q8IXW5
TAP
24981860
种属内
RPRD1B Q9NQG5 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
种属内
RPRD1B Q9NQG5 SPG21 Homo sapiens Q9NZD8
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
DLS
24997600
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
Crosslink
24997600
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
X-Ray Diffraction
24997600
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
GMS
24997600
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
Solution Sedimentation
24997600
种属内
RPRD1B Q9NQG5 RPRD1B Homo sapiens Q9NQG5
Y2H Array
32296183
种属内
RPRD1B Q9NQG5 CDCA8 Homo sapiens Q53HL2
Y2H Prey Pooling
32296183
种属内
RPRD1B Q9NQG5 CDCA8 Homo sapiens Q53HL2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polyneuropathy Due To Drug
Retroperitoneal Leiomyosarcoma
Inflammatory And Toxic Neuropathy
Retroperitoneal Sarcoma
Atrial Tachyarrhythmia With Short Pr Interval

Lown-Ganong-Levine Syndrome

Syndrome Of Short P-R Interval, Normal Qrs Complexes, And Supraventricular Tachycardias

Lgl Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RPRD1B VGNC VGNC:34127
Canis familiaris RPRD1B VGNC VGNC:45727
Felis catus RPRD1B VGNC VGNC:64749
Macaca mulatta RPRD1B VGNC VGNC:77024
Mus musculus RPRD1B MGD MGI:1917720
Rattus norvegicus RPRD1B RGD RGD:1304782
Others RPRD1B NCBI