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  2. RPAP2 - RNA polymerase II associated protein 2 Gene

RPAP2 - RNA polymerase II associated protein 2 Gene

中文名称:RNA 聚合酶 II 相关蛋白 2

种属: Homo sapiens

同用名: Rtr1; C1orf82

基因 ID: 79871 | 基因类型: protein coding

关于 RPAP2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,299,059-92,402,056 (from NCBI)

This gene has 3 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues.

功能概要

启用 RNA 聚合酶 II CTD 七肽重复磷酸酶活性。参与 RNA 聚合酶 II C 末端结构域的去磷酸化和 snRNA 转录。位于胞质溶胶和核仁中。 RNA 聚合酶 II 的一部分,全酶。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and snRNA transcription. Located in cytosol and nucleolus. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]

RPAP2 基因产物(1)

mRNA Protein Name
NM_024813.3 NP_079089.2 putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IMP
IMP: 通过突变表型推断
22137580 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24656813 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
30118681 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in PERK-mediated unfolded protein response IDA
IDA: 通过直接分析推断
30118681 GOA
involved in snRNA transcription IMP
IMP: 通过突变表型推断
22137580 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
22137580 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22137580 GOA
part of transcription preinitiation complex IDA
IDA: 通过直接分析推断
22231121 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPAP2 蛋白结构

RPAP2_Rtr1

RPAP2_Rtr1: Rtr1/RPAP2 family (80 - 152)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 612 a.a.
蛋白主名 其他名称

putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

RPAP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPAP2 Q8IXW5 RPRD1A Homo sapiens Q96P16-1
Pull Down
24997600
种属内
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
种属内
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
种属内
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Anti Tag CoIP
35271311
种属内
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
种属内
RPAP2 Q8IXW5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
种属内
RPAP2 Q8IXW5 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属内
RPAP2 Q8IXW5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
种属内
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Anti Tag CoIP
35271311
种属内
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Y2H Prey Pooling
32296183
种属内
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
TAP
24981860
种属内
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Y2H Array
32296183
种属内
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Validated Y2H
32296183
种属内
RPAP2 Q8IXW5 RPRD1B Homo sapiens Q9NQG5
Pull Down
24997600
种属内
RPAP2 Q8IXW5 RPRD1B Homo sapiens Q9NQG5
ITC
24997600
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1

Intrahepatic Cholestasis Of Pregnancy 1

Cholestasis, Pregnancy-Related, 1

Pregnancy Related Cholestasis 1

Cholestasis Of Pregnancy, Intrahepatic 1

Obstetric Cholestasis

Pregnancy-Related Cholestasis

Recurrent Intrahepatic Cholestasis Of Pregnancy

Cholestasis, Intrahepatic, Of Pregnancy, Type 1

Cholestasis Of Pregnancy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus RPAP2 VGNC VGNC:64729
Rattus norvegicus RPAP2 RGD RGD:1309034
Mus musculus RPAP2 MGD MGI:2141142
Bos taurus RPAP2 VGNC VGNC:34099
Macaca mulatta RPAP2 VGNC VGNC:76828