MTMR3 - myotubularin related protein 3 Gene

中文名称：肌微管蛋白相关蛋白 3

种属: Homo sapiens

同用名: ZFYVE10; FYVE-DSP1

关于 MTMR3

功能概要

该基因编码肌微管蛋白双重特异性蛋白磷酸酶基因家族的成员。编码的蛋白质在结构上类似于肌微管蛋白，但还包含一个 FYVE 结构域和一个 N 端 PH-GRAM 结构域。该蛋白可以自缔合，也可以与另一种肌微管蛋白相关蛋白形成异聚体。该蛋白通过 PH-GRAM 结构域与磷酸肌醇脂质结合，并可在体外水解磷脂酰肌醇 (3) -磷酸和磷脂酰肌醇 (3,5) -二磷酸。已观察到编码的蛋白质在细胞中具有核周分布，可能是膜结合分布，但也发现它游离在细胞质中。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the myotubularin dual specificity protein Phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]