1. Gene
  2. HOXB5 - homeobox B5 Gene

HOXB5 - homeobox B5 Gene

中文名称:同源框 B5

种属: Homo sapiens

同用名: HOX2; HU-1; HOX2A; Hox2.1; HHO.C10

基因 ID: 3215 | 基因类型: protein coding

关于 HOXB5

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,591,257-48,593,779 (from NCBI)

This gene has 1 transcript (splice variant), 258 orthologues and 42 paralogues. Biased expression in kidney (RPKM 6.1), colon (RPKM 5.0) and 13 other tissues.

功能概要

该基因是 Antp 同源框家族的成员,编码具有同源框 DNA 结合域的核蛋白。它包含在位于 17 号染色体上的同源盒 B 基因簇中。编码的蛋白质作为一种序列特异性转录因子起作用,参与肺和肠道发育。该基因表达增加与急性髓性白血病 (AML) 的独特生物学亚群以及支气管肺隔离症 (BPS) 和先天性囊性腺瘤样畸形 (CCAM) 组织的发生有关。[RefSeq 提供,2008 年 7 月]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]

HOXB5 基因产物(1)

mRNA Protein Name
NM_002147.4 NP_002138.1 homeobox protein Hox-B5
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HOXB5 蛋白结构

Homeobox

Homeobox: Homeobox domain (195 - 251)

  • 0
  • 100
  • 200
  • 269 a.a.
蛋白主名 其他名称

homeobox protein Hox-B5

homeo box 2A

HOXB5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HOXB5 P09067 KRTAP10-8 Homo sapiens P60410 32296183
种属内
HOXB5 P09067 KRTAP10-8 Homo sapiens P60410 32296183
种属内
HOXB5 P09067 KRTAP10-8 Homo sapiens P60410 32296183
种属内
HOXB5 P09067 CTBP1 Homo sapiens Q13363-2 25416956
种属内
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 32296183
种属内
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 25416956
种属内
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 25416956
种属内
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 32296183
种属内
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 32296183
种属内
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 25416956
种属内
HOXB5 P09067 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
HOXB5 P09067 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
HOXB5 P09067 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
HOXB5 P09067 MAGEA11 Homo sapiens P43364-2 25416956
种属内
HOXB5 P09067 CADPS Homo sapiens A2RRN7 32296183
种属内
HOXB5 P09067 CADPS Homo sapiens A2RRN7 32296183
种属内
HOXB5 P09067 ZNF774 Homo sapiens Q6NX45 32296183
种属内
HOXB5 P09067 ZNF774 Homo sapiens Q6NX45 32296183
种属内
HOXB5 P09067 ZNF774 Homo sapiens Q6NX45 32296183
种属内
HOXB5 P09067 NFKBID Homo sapiens Q8NI38 32296183
种属内
HOXB5 P09067 NFKBID Homo sapiens Q8NI38 32296183
种属内
HOXB5 P09067 NFKBID Homo sapiens Q8NI38 32296183
种属内
HOXB5 P09067 PBX4 Homo sapiens Q9BYU1 32296183
种属内
HOXB5 P09067 PBX4 Homo sapiens Q9BYU1 32296183
种属内
HOXB5 P09067 PBX4 Homo sapiens Q9BYU1 32296183
种属内
HOXB5 P09067 KRT34 Homo sapiens O76011 32296183
种属内
HOXB5 P09067 KRT34 Homo sapiens O76011 32296183
种属内
HOXB5 P09067 ZNF286A Homo sapiens Q9HBT8 32296183
种属内
HOXB5 P09067 ZNF286A Homo sapiens Q9HBT8 32296183
种属内
HOXB5 P09067 ZNF286A Homo sapiens Q9HBT8 32296183
种属内
HOXB5 P09067 HOOK2 Homo sapiens Q96ED9-2 32296183
种属内
HOXB5 P09067 HOOK2 Homo sapiens Q96ED9-2 32296183
种属内
HOXB5 P09067 HOOK2 Homo sapiens Q96ED9-2 32296183
种属内
HOXB5 P09067 GOLGA6A Homo sapiens Q9NYA3 32296183
种属内
HOXB5 P09067 GOLGA6A Homo sapiens Q9NYA3 32296183
种属内
HOXB5 P09067 GOLGA6A Homo sapiens Q9NYA3 32296183
种属内
HOXB5 P09067 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
HOXB5 P09067 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
HOXB5 P09067 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
HOXB5 P09067 TEX11 Homo sapiens Q8IYF3-3 32296183
种属内
HOXB5 P09067 TEX11 Homo sapiens Q8IYF3-3 32296183
种属内
HOXB5 P09067 TEX11 Homo sapiens Q8IYF3-3 32296183
种属内
HOXB5 P09067 CARD9 Homo sapiens Q9H257-2 32296183
种属内
HOXB5 P09067 CARD9 Homo sapiens Q9H257-2 32296183
种属内
HOXB5 P09067 CARD9 Homo sapiens Q9H257-2 32296183
种属内
HOXB5 P09067 TLE5 Homo sapiens Q08117-2 32296183
种属内
HOXB5 P09067 TLE5 Homo sapiens Q08117-2 32296183
种属内
HOXB5 P09067 TLE5 Homo sapiens Q08117-2 32296183
种属内
HOXB5 P09067 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
HOXB5 P09067 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
HOXB5 P09067 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
HOXB5 P09067 KRTAP10-6 Homo sapiens P60371 32296183
种属内
HOXB5 P09067 KRTAP10-6 Homo sapiens P60371 32296183
种属内
HOXB5 P09067 KRTAP10-6 Homo sapiens P60371 32296183
种属内
HOXB5 P09067 ZMYND12 Homo sapiens Q9H0C1 32296183
种属内
HOXB5 P09067 ZMYND12 Homo sapiens Q9H0C1 32296183
种属内
HOXB5 P09067 ZMYND12 Homo sapiens Q9H0C1 32296183
种属内
HOXB5 P09067 CNFN Homo sapiens Q9BYD5 32296183
种属内
HOXB5 P09067 CNFN Homo sapiens Q9BYD5 32296183
种属内
HOXB5 P09067 CNFN Homo sapiens Q9BYD5 32296183
种属内
HOXB5 P09067 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
HOXB5 P09067 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
HOXB5 P09067 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
HOXB5 P09067 SIRT1 Homo sapiens Q96EB6 33961781
种属内
HOXB5 P09067 SIRT1 Homo sapiens Q96EB6 28514442
种属内
HOXB5 P09067 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
HOXB5 P09067 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
HOXB5 P09067 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
HOXB5 P09067 KRTAP6-3 Homo sapiens Q3LI67 32296183
种属内
HOXB5 P09067 KRTAP6-3 Homo sapiens Q3LI67 32296183
种属内
HOXB5 P09067 PHF19 Homo sapiens Q5T6S3 32296183
种属内
HOXB5 P09067 PHF19 Homo sapiens Q5T6S3 32296183
种属内
HOXB5 P09067 PHF19 Homo sapiens Q5T6S3 32296183
种属内
HOXB5 P09067 ZNF552 Homo sapiens Q9H707 32296183
种属内
HOXB5 P09067 ZNF552 Homo sapiens Q9H707 32296183
种属内
HOXB5 P09067 ZNF552 Homo sapiens Q9H707 32296183
种属内
HOXB5 P09067 VPS52 Homo sapiens Q8N1B4 32296183
种属内
HOXB5 P09067 VPS52 Homo sapiens Q8N1B4 32296183
种属内
HOXB5 P09067 VPS52 Homo sapiens Q8N1B4 32296183
种属内
HOXB5 P09067 PBX1 Homo sapiens P40424 32296183
种属内
HOXB5 P09067 PBX1 Homo sapiens P40424 32296183
种属内
HOXB5 P09067 PBX1 Homo sapiens P40424 32296183
种属内
HOXB5 P09067 PLXND1 Homo sapiens Q9Y4D7 32296183
种属内
HOXB5 P09067 PLXND1 Homo sapiens Q9Y4D7 32296183
种属内
HOXB5 P09067 PLXND1 Homo sapiens Q9Y4D7 32296183
种属内
HOXB5 P09067 CCDC88B Homo sapiens A6NC98 32296183
种属内
HOXB5 P09067 CCDC88B Homo sapiens A6NC98 32296183
种属内
HOXB5 P09067 CSNK2B Homo sapiens P67870 32296183
种属内
HOXB5 P09067 CSNK2B Homo sapiens P67870 32296183
种属内
HOXB5 P09067 CSNK2B Homo sapiens P67870 32296183
种属内
HOXB5 P09067 PBX2 Homo sapiens P40425 32296183
种属内
HOXB5 P09067 PBX2 Homo sapiens P40425 32296183
种属内
HOXB5 P09067 PBX2 Homo sapiens P40425 32296183
种属内
HOXB5 P09067 TRAF2 Homo sapiens Q12933 32296183
种属内
HOXB5 P09067 TRAF2 Homo sapiens Q12933 32296183
种属内
HOXB5 P09067 TRAF2 Homo sapiens Q12933 32296183
种属内
HOXB5 P09067 TRAF1 Homo sapiens Q13077 32296183
种属内
HOXB5 P09067 TRAF1 Homo sapiens Q13077 32296183
种属内
HOXB5 P09067 TRAF1 Homo sapiens Q13077 32296183
种属内
HOXB5 P09067 TRAF4 Homo sapiens Q9BUZ4 32296183
种属内
HOXB5 P09067 TRAF4 Homo sapiens Q9BUZ4 32296183
种属内
HOXB5 P09067 TRAF4 Homo sapiens Q9BUZ4 32296183
种属内
HOXB5 P09067 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
HOXB5 P09067 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
HOXB5 P09067 PRDM14 Homo sapiens Q9GZV8 32296183
种属内
HOXB5 P09067 PRDM14 Homo sapiens Q9GZV8 32296183
种属内
HOXB5 P09067 PRDM14 Homo sapiens Q9GZV8 32296183
种属内
HOXB5 P09067 AXIN2 Homo sapiens Q9Y2T1 32296183
种属内
HOXB5 P09067 AXIN2 Homo sapiens Q9Y2T1 32296183
种属内
HOXB5 P09067 AXIN2 Homo sapiens Q9Y2T1 32296183
种属内
HOXB5 P09067 TRIB3 Homo sapiens Q96RU7 32296183
种属内
HOXB5 P09067 TRIB3 Homo sapiens Q96RU7 32296183
种属内
HOXB5 P09067 TRIB3 Homo sapiens Q96RU7 32296183
种属内
HOXB5 P09067 ZRANB1 Homo sapiens Q9UGI0 32296183
种属内
HOXB5 P09067 ZRANB1 Homo sapiens Q9UGI0 32296183
种属内
HOXB5 P09067 ZRANB1 Homo sapiens Q9UGI0 32296183
种属内
HOXB5 P09067 OIP5 Homo sapiens O43482 32296183
种属内
HOXB5 P09067 OIP5 Homo sapiens O43482 32296183
种属内
HOXB5 P09067 GOLGA6L9 Homo sapiens A6NEM1 32296183
种属内
HOXB5 P09067 GOLGA6L9 Homo sapiens A6NEM1 32296183
种属内
HOXB5 P09067 GOLGA2 Homo sapiens Q08379 32296183
种属内
HOXB5 P09067 GOLGA2 Homo sapiens Q08379 32296183
种属内
HOXB5 P09067 GOLGA2 Homo sapiens Q08379 32296183
种属内
HOXB5 P09067 ZNF655 Homo sapiens Q8N720 32296183
种属内
HOXB5 P09067 ZNF655 Homo sapiens Q8N720 32296183
种属内
HOXB5 P09067 ZNF655 Homo sapiens Q8N720 32296183
种属内
HOXB5 P09067 ASB6 Homo sapiens Q9NWX5 32296183
种属内
HOXB5 P09067 ASB6 Homo sapiens Q9NWX5 32296183
种属内
HOXB5 P09067 ASB6 Homo sapiens Q9NWX5 32296183
种属内
HOXB5 P09067 HSF2BP Homo sapiens O75031 32296183
种属内
HOXB5 P09067 HSF2BP Homo sapiens O75031 32296183
种属内
HOXB5 P09067 HAP1 Homo sapiens P54257 32296183
种属内
HOXB5 P09067 HAP1 Homo sapiens P54257 32296183
种属内
HOXB5 P09067 HAP1 Homo sapiens P54257 32296183
种属内
HOXB5 P09067 TRIM27 Homo sapiens P14373 32296183
种属内
HOXB5 P09067 TRIM27 Homo sapiens P14373 32296183
种属内
HOXB5 P09067 TRIM27 Homo sapiens P14373 32296183
种属内
HOXB5 P09067 MAGEA11 Homo sapiens P43364 32296183
种属内
HOXB5 P09067 MAGEA11 Homo sapiens P43364 32296183
种属内
HOXB5 P09067 MAGEA11 Homo sapiens P43364 32296183
种属内
HOXB5 P09067 CALCOCO2 Homo sapiens Q13137 32296183
种属内
HOXB5 P09067 CALCOCO2 Homo sapiens Q13137 32296183
种属内
HOXB5 P09067 CALCOCO2 Homo sapiens Q13137 32296183
种属内
HOXB5 P09067 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
HOXB5 P09067 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
HOXB5 P09067 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
HOXB5 P09067 TRIM23 Homo sapiens P36406 32296183
种属内
HOXB5 P09067 TRIM23 Homo sapiens P36406 32296183
种属内
HOXB5 P09067 TRIM23 Homo sapiens P36406 32296183
种属内
HOXB5 P09067 TRIM23 Homo sapiens P36406 25416956
种属内
HOXB5 P09067 LDOC1 Homo sapiens O95751 32296183
种属内
HOXB5 P09067 LDOC1 Homo sapiens O95751 32296183
种属内
HOXB5 P09067 ZC4H2 Homo sapiens Q9NQZ6 32296183
种属内
HOXB5 P09067 ZC4H2 Homo sapiens Q9NQZ6 32296183
种属内
HOXB5 P09067 ZC4H2 Homo sapiens Q9NQZ6 32296183
种属内
HOXB5 P09067 HOMER3 Homo sapiens Q9NSC5 32296183
种属内
HOXB5 P09067 HOMER3 Homo sapiens Q9NSC5 32296183
种属内
HOXB5 P09067 HOMER3 Homo sapiens Q9NSC5 32296183
种属内
HOXB5 P09067 TEKT4 Homo sapiens Q8WW24 32296183
种属内
HOXB5 P09067 TEKT4 Homo sapiens Q8WW24 32296183
种属内
HOXB5 P09067 TEKT4 Homo sapiens Q8WW24 32296183
种属内
HOXB5 P09067 USH1G Homo sapiens Q495M9 32296183
种属内
HOXB5 P09067 USH1G Homo sapiens Q495M9 32296183
种属内
HOXB5 P09067 USH1G Homo sapiens Q495M9 32296183
种属内
HOXB5 P09067 KRT31 Homo sapiens Q15323 32296183
种属内
HOXB5 P09067 KRT31 Homo sapiens Q15323 32296183
种属内
HOXB5 P09067 KRT31 Homo sapiens Q15323 32296183
种属内
HOXB5 P09067 KIFAP3 Homo sapiens Q92845 32296183
种属内
HOXB5 P09067 KIFAP3 Homo sapiens Q92845 32296183
种属内
HOXB5 P09067 KIFAP3 Homo sapiens Q92845 32296183
种属内
HOXB5 P09067 PDE4DIP Homo sapiens Q5VU43-2 32296183
种属内
HOXB5 P09067 PDE4DIP Homo sapiens Q5VU43-2 32296183
种属内
HOXB5 P09067 PDE4DIP Homo sapiens Q5VU43-2 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hereditary Lymphedema Ia

Lmph1a

Lymphedema, Hereditary, Ia

Milroy Disease

Barrett Esophagus

Barrett'S Esophagus

Barrett Esophagus/Esophageal Adenocarcinoma

Barrett Metaplasia

Barrett'S Ulcer Of Esophagus

Ulcerative Esophagitis

Barrett'S Esophagus With Esophagitis

Barrett'S Oesophagus

Barretts Syndrome

Barrett Syndrome

BE

Peptic Ulcer Of Esophagus

Adenocarcinoma Of Esophagus

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus HOXB5 VGNC VGNC:58381
Rattus norvegicus HOXB5 RGD RGD:1562292
Canis familiaris HOXB5 VGNC VGNC:54956
Macaca mulatta HOXB5 VGNC VGNC:104619
Felis catus HOXB5 VGNC VGNC:99080
Mus musculus HOXB5 MGD MGI:96186