2. Gene
  3. PLXND1 - plexin D1 Gene

PLXND1 - plexin D1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丛素 D1

种属: Homo sapiens

同用名: PLEXD1

基因 ID: 23129 | 基因类型: protein coding

关于 PLXND1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:129,555,214-129,606,676 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues, 8 paralogues and is associated with 4 phenotypes. Broad expression in placenta (RPKM 37.7), fat (RPKM 32.1) and 23 other tissues.

功能概要

启用蛋白质域特异性结合活性。预计参与多个过程，包括内皮细胞迁移；神经系统发育；和血管生成的调节。预计在几个过程的上游或内部起作用，包括循环系统发育；参与唾液腺分支的末端单位的二分法细分；和蛋白质结合活性的正调节。位于 lamellipodium。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein domain specific binding activity. Predicted to be involved in several processes, including endothelial cell migration; nervous system development; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and positive regulation of protein binding activity. Located in lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]

PLXND1 基因产物(1)

mRNA Protein Name
NM_015103.3 NP_055918.3 plexin-D1 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17318185 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
24841563 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lamellipodium IDA
IDA: 通过直接分析推断
24841563 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLXND1 蛋白结构

Sema

Sema: Sema domain (63 - 155)

Sema

Sema: Sema domain (279 - 521)

PSI

PSI: Plexin repeat (549 - 601)

PSI

PSI: Plexin repeat (702 - 753)

TIG

TIG: IPT/TIG domain (891 - 976)

TIG

TIG: IPT/TIG domain (981 - 1063)

TIG

TIG: IPT/TIG domain (1069 - 1143)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1344 - 1888)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1925 a.a.
蛋白主名 其他名称

plexin-D1

PLXND1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PLXND1 Q9Y4D7 NR4A1 Homo sapiens P22736
Pull Down
24139859
Intra PLXND1 Q9Y4D7 NR4A1 Homo sapiens P22736
Y2H
24139859
Cross PLXND1 Q9Y4D7 Sema3e Mus musculus P70275
Pull Down
24139859
Cross PLXND1 Q9Y4D7 Sema3e Mus musculus P70275
Competition Binding
24139859
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Moebius Syndrome

Mobius Syndrome

Moebius Sequence

Oromandibular-Limb Hypogenesis Spectrum

Congenital Facial Diplegia

MBS

Moebius Congenital Oculofacial Paralysis

Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves

Congenital Facial Diplegia Syndrome

Congenital Oculofacial Paralysis

Congenital Ophthalmoplegia And Facial Paresis

Moebius Spectrum

Möbius Sequence

Möbius Syndrome

Mobius Ii Syndrome
Conotruncal Heart Malformations

Persistent Truncus Arteriosus

Conotruncal Anomaly Face Syndrome

Truncus Arteriosus

Common Arterial Trunk

CTHM

Conotruncal Heart Malformations, Variable

Tac

Truncus Arteriosus Communis

Conotruncal Cardiac Defects

Common Aorticopulmonary Trunk

Cafs

Conotruncal Heart Defects

Cthd

Dorv

Double-Outlet Right Ventricle

Pta

Heart Malformations, Conotruncal

Common Truncus

Common Truncus Arteriosus

Persistent Truncus Arteriosus Or Communis

Truncus Communis

Common Aortico-Pulmonary Trunk

Truncus Arteriosus With Aortic Dominance

Truncus Arteriosus With No Aortic Obstruction

Truncus Arteriosus With Pulmonary Dominance And Interrupted Aortic Arch

Truncus Arteriosus With Interrupted Aortic Arch

Common Arterial Trunk With Interrupted Aortic Arch

Van Praagh Truncus Arteriosus Type A4
Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome

CFZS

Congenital Nonprogressive Myopathy With Moebius And Robin Sequences

Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence

Cfz Syndrome

Carey Fineman Ziter Syndrome

Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences

Myopathy-Moebius-Robin Syndrome

CFZS1

Moebius Sequence, Robin Complex, And Hypotonia

Congenital Non-Progressive Myopathy With Moebius And Robin Sequences
Spinocerebellar Ataxia 44

SCA44
Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome

SCDO1

Vertebral Anomalies

Spondylothoracic Dysplasia

Costovertebral Dysplasia

Spondylothoracic Dysostosis

Spondylocostal Dysostosis 1

Autosomal Recessive Spondylocostal Dysostosis 1

Spondylocostal Dysostosis, Autosomal Recessive, 1

Doid:0112365

Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10756 PLXND1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLXND1 RGD RGD:1310796
Macaca mulatta PLXND1 VGNC VGNC:76191
Bos taurus PLXND1 VGNC VGNC:33065
Canis familiaris PLXND1 VGNC VGNC:44726
Mus musculus PLXND1 MGD MGI:2154244
Felis catus PLXND1 VGNC VGNC:80659
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z