2. Gene
  3. PBX2 - PBX homeobox 2 Gene

PBX2 - PBX homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PBX 同源盒 2

种属: Homo sapiens

同用名: G17; HOX12; PBX2MHC

基因 ID: 5089 | 基因类型: protein coding

关于 PBX2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,184,733-32,190,202 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 132 orthologues and 12 paralogues. Ubiquitous expression in placenta (RPKM 34.1), spleen (RPKM 33.9) and 25 other tissues.

功能概要

该基因编码 TALE/PBX 同源盒家族中一个普遍表达的成员。它通过与参与急性前 B 细胞白血病中 t (1;19) 易位的同源盒基因的相似性得到鉴定。该蛋白是一种转录激活剂，可与 TLX1 启动子结合。该基因位于 6 号染色体上的主要组织相容性复合体 (MHC) 内。[RefSeq 提供，2008 年 7 月]

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

PBX2 基因产物(1)

mRNA Protein Name
NM_002586.5 NP_002577.2 pre-B-cell leukemia transcription factor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19356220 GOA
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
18973687 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12054735 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19559479 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19356220 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18973687 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PBX2 蛋白结构

PBC

PBC: PBC domain (50 - 243)

Homeobox

Homeobox: Homeobox domain (245 - 304)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 430 a.a.
蛋白主名 其他名称

pre-B-cell leukemia transcription factor 2

XXbac-BPG300A18.13

PBX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PBX2 P40425 BFSP2 Homo sapiens Q13515
Validated Y2H
32296183
Intra PBX2 P40425 RIPPLY2 Homo sapiens Q5TAB7
Complementation
32296183
Intra PBX2 P40425 RIPPLY2 Homo sapiens Q5TAB7
Validated Y2H
32296183
Intra PBX2 P40425 PPFIBP1 Homo sapiens Q86W92
Validated Y2H
32296183
Intra PBX2 P40425 HOXC5 Homo sapiens Q00444
Validated Y2H
32296183
Intra PBX2 P40425 ZCWPW2 Homo sapiens Q504Y3
Validated Y2H
32296183
Intra PBX2 P40425 PKNOX1 Homo sapiens P55347
Y2H
19559479
Intra PBX2 P40425 TLX1 Homo sapiens P31314
Y2H
19559479
Intra PBX2 P40425 BLOC1S5 Homo sapiens Q8TDH9
Validated Y2H
32296183
Intra PBX2 P40425 CDCA7L Homo sapiens Q96GN5
Validated Y2H
32296183
Intra PBX2 P40425 BRMS1L Homo sapiens Q5PSV4
Validated Y2H
32296183
Intra PBX2 P40425 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra PBX2 P40425 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra PBX2 P40425 HOXA1 Homo sapiens P49639
Validated Y2H
25416956
Intra PBX2 P40425 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
25416956
Intra PBX2 P40425 HOXA1 Homo sapiens P49639
Y2H Array
25416956
Intra PBX2 P40425 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
Intra PBX2 P40425 CARD9 Homo sapiens Q9H257
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10107 PBX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PBX2 VGNC VGNC:75771
Mus musculus PBX2 MGD MGI:1341793
Canis familiaris PBX2 VGNC VGNC:44287
Bos taurus PBX2 VGNC VGNC:32608
Rattus norvegicus PBX2 RGD RGD:1303084
Felis catus PBX2 VGNC VGNC:68707
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