HOXC5 - homeobox C5 Gene

中文名称：同源框 C5

种属: Homo sapiens

同用名: CP11; HOX3; HOX3D

关于 HOXC5

功能概要

该基因属于同源盒基因家族。同源框基因编码一个高度保守的转录因子家族，在所有多细胞生物的形态发生中起着重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因 HOXC5 是位于 12 号染色体簇中的几个同源框 HOXC 基因之一。三个基因 HOXC5、HOXC4 和 HOXC6 共享一个 5' 非编码外显子。转录本可能包括与基因特异性外显子剪接的共享外显子，或者它们可能仅包括基因特异性外显子。已经为 HOXC5 描述了两种可变剪接变体。包含共享外显子的转录变体显然不编码蛋白质。蛋白质编码转录变体仅包含基因特异性外显子。[RefSeq 提供，2008 年 7 月]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]