PPFIBP1 - PPFIA binding protein 1 Gene

中文名称：PPFIA 结合蛋白 1

种属: Homo sapiens

同用名: L2; SGT2; hSGT2; hSgt2p; NEDSMBA

关于 PPFIBP1

功能概要

该基因编码的蛋白质是 LAR 蛋白-酪氨酸磷酸酶相互作用蛋白 (liprin) 家族的成员。脂蛋白与跨膜蛋白酪氨酸磷酸酶 LAR 家族的成员相互作用，已知后者对轴突导向和乳腺发育很重要。已经提出，脂蛋白是形成复杂结构的多价蛋白质，并充当用于募集和锚定 LAR 酪氨酸磷酸酶家族的支架。发现该蛋白质与 S100A4 相互作用，S100A4 是一种与肿瘤侵袭和转移相关的钙结合蛋白。体外实验表明，这种相互作用抑制了蛋白激酶 C 和蛋白激酶 CK2 对该蛋白的磷酸化。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane Protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]