2. Gene
  3. PKNOX1 - PBX/knotted 1 homeobox 1 Gene

PKNOX1 - PBX/knotted 1 homeobox 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PBX/结 1 同源盒 1

种属: Homo sapiens

同用名: PREP1; pkonx1c

基因 ID: 5316 | 基因类型: protein coding

关于 PKNOX1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,974,562-43,033,931 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.8) and 25 other tissues.

功能概要

启用序列特异性双链 DNA 结合活性。预计通过 RNA 聚合酶 II 参与血管生成和转录调节。预计在照相机式眼睛发育的上游或内部起作用；造血作用；和 RNA 聚合酶 II 对转录的正调控。预测位于细胞质和细胞核中。预测是染色质的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in angiogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

PKNOX1 基因产物(3)

mRNA Protein Name
NM_001286258.2 NP_001273187.1 homeobox protein PKNOX1 isoform 2
NM_001320694.2 NP_001307623.1 homeobox protein PKNOX1 isoform 3
NM_004571.5 NP_004562.2 homeobox protein PKNOX1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19559479 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PKNOX1 蛋白结构

Homeobox_KN

Homeobox_KN: Homeobox KN domain (277 - 316)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
蛋白主名 其他名称

homeobox protein PKNOX1

PBX/knotted homeobox 1

PKNOX1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PKNOX1 P55347 BORCS6 Homo sapiens Q96GS4
Complementation
32296183
种属内
PKNOX1 P55347 BORCS6 Homo sapiens Q96GS4
Validated Y2H
32296183
种属内
PKNOX1 P55347 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
种属内
PKNOX1 P55347 HMGB2 Homo sapiens P26583
Y2H Prey Pooling
32296183
种属内
PKNOX1 P55347 FAM110B Homo sapiens Q8TC76
Validated Y2H
32296183
种属内
PKNOX1 P55347 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32296183
种属内
PKNOX1 P55347 PBX1 Homo sapiens P40424
Anti Tag CoIP
33961781
种属内
PKNOX1 P55347 PBX1 Homo sapiens P40424
Comigration in SDS
25856340
种属内
PKNOX1 P55347 PBX1 Homo sapiens P40424
GMS
25856340
种属内
PKNOX1 P55347 PBX1 Homo sapiens P40424
Y2H Fragment Pooling
35914814
种属内
PKNOX1 P55347 PBX2 Homo sapiens P40425
Y2H Fragment Pooling
35914814
种属内
PKNOX1 P55347 PBX2 Homo sapiens P40425
Imaging
9482739
种属内
PKNOX1 P55347 PBX2 Homo sapiens P40425
Y2H
19559479
种属内
PKNOX1 P55347 PBX2 Homo sapiens P40425
Anti Tag CoIP
33961781
种属内
PKNOX1 P55347 BLOC1S5 Homo sapiens Q8TDH9
Validated Y2H
32296183
种属内
PKNOX1 P55347 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
种属内
PKNOX1 P55347 MPP3 Homo sapiens Q13368
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Epilepsy, Familial Temporal Lobe, 4

ETL4

Epilepsy, Occipitotemporal Lobe, And Migraine With Aura

Epolm

Familial Temporal Lobe Epilepsy 4

Occipitotemporal Lobe Epilepsy And Migraine With Aura
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10609 PKNOX1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PKNOX1 VGNC VGNC:44614
Macaca mulatta PKNOX1 VGNC VGNC:76150
Felis catus PKNOX1 VGNC VGNC:102804
Rattus norvegicus PKNOX1 RGD RGD:1305003
Bos taurus PKNOX1 VGNC VGNC:32948
Mus musculus PKNOX1 MGD MGI:1201409
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