1. Gene
  2. SYTL4 - synaptotagmin like 4 Gene

SYTL4 - synaptotagmin like 4 Gene

中文名称:突触结合蛋白 4

种属: Homo sapiens

同用名: SLP4

基因 ID: 94121 | 基因类型: protein coding

关于 SYTL4

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,674,491-100,732,121 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 31 paralogues. Broad expression in ovary (RPKM 19.6), endometrium (RPKM 12.8) and 19 other tissues.

功能概要

该基因编码突触结合蛋白样蛋白家族的成员。该家族成员的特征在于 N 端 Rab27 结合域和 C 端串联 C2 域。编码的蛋白质结合特定的小 Rab GTP 酶并参与细胞内膜运输。这种蛋白质结合 Rab27 并可能参与抑制致密核心囊泡胞吐作用。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供,2010 年 3 月]

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

SYTL4 基因产物(13)

mRNA Protein Name
NM_001129896.3 NP_001123368.1 synaptotagmin-like protein 4 isoform 1
NM_001174068.2 NP_001167539.1 synaptotagmin-like protein 4 isoform 1
NM_001370160.1 NP_001357089.1 synaptotagmin-like protein 4 isoform 1
NM_001370161.1 NP_001357090.1 synaptotagmin-like protein 4 isoform 1
NM_001370162.1 NP_001357091.1 synaptotagmin-like protein 4 isoform 2
NM_001370163.1 NP_001357092.1 synaptotagmin-like protein 4 isoform 1
NM_001370164.1 NP_001357093.1 synaptotagmin-like protein 4 isoform 1
NM_001370165.1 NP_001357094.1 synaptotagmin-like protein 4 isoform 1
NM_001370166.1 NP_001357095.1 synaptotagmin-like protein 4 isoform 1
NM_001370167.1 NP_001357096.1 synaptotagmin-like protein 4 isoform 1
NM_001370168.1 NP_001357097.1 synaptotagmin-like protein 4 isoform 1
NM_001370169.1 NP_001357098.1 synaptotagmin-like protein 4 isoform 1
NM_080737.3 NP_542775.2 synaptotagmin-like protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lysosome localization IMP
IMP: 通过突变表型推断
2732579 GOA
involved in multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
19966785 GOA
involved in plasma membrane repair IDA
IDA: 通过直接分析推断
27325790 GOA
involved in positive regulation of exocytosis IMP
IMP: 通过突变表型推断
19966785 GOA
involved in positive regulation of protein secretion IMP
IMP: 通过突变表型推断
19966785 GOA
involved in regulation of plasma membrane repair IMP
IMP: 通过突变表型推断
2732579 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
19966785 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SYTL4 蛋白结构

FYVE_2

FYVE_2: FYVE-type zinc finger (10 - 122)

C2

C2: C2 domain (373 - 461)

C2

C2: C2 domain (528 - 616)

  • 0
  • 200
  • 400
  • 600
  • 671 a.a.
蛋白主名 其他名称

synaptotagmin-like protein 4

exophilin-2

SYTL4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SYTL4 Q96C24 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 OSBPL3 Homo sapiens Q9H4L5
Validated Y2H
32296183
种属内
SYTL4 Q96C24 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
种属内
SYTL4 Q96C24 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
种属内
SYTL4 Q96C24 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
种属内
SYTL4 Q96C24 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
种属内
SYTL4 Q96C24 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
种属内
SYTL4 Q96C24 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
种属内
SYTL4 Q96C24 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
种属内
SYTL4 Q96C24 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
种属内
SYTL4 Q96C24 TBC1D1 Homo sapiens Q86TI0
Y2H Array
32296183
种属内
SYTL4 Q96C24 TBC1D1 Homo sapiens Q86TI0
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
种属内
SYTL4 Q96C24 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 ZBTB9 Homo sapiens Q96C00
Y2H Array
32296183
种属内
SYTL4 Q96C24 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
种属内
SYTL4 Q96C24 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
种属内
SYTL4 Q96C24 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
种属内
SYTL4 Q96C24 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
种属内
SYTL4 Q96C24 DVL3 Homo sapiens Q92997
Y2H Array
32296183
种属内
SYTL4 Q96C24 ZBTB7B Homo sapiens O15156
Validated Y2H
25416956
种属内
SYTL4 Q96C24 ZBTB7B Homo sapiens O15156
Y2H Prey Pooling
25416956
种属内
SYTL4 Q96C24 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 FXR2 Homo sapiens P51116
Y2H Array
32296183
种属内
SYTL4 Q96C24 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
25416956
种属内
SYTL4 Q96C24 HMG20A Homo sapiens Q9NP66
Validated Y2H
25416956
种属内
SYTL4 Q96C24 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
种属内
SYTL4 Q96C24 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
种属内
SYTL4 Q96C24 TRIM37 Homo sapiens O94972
Y2H Prey Pooling
32296183
种属内
SYTL4 Q96C24 TRIM37 Homo sapiens O94972
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SYTL4 VGNC VGNC:47053
Macaca mulatta SYTL4 VGNC VGNC:78124
Mus musculus SYTL4 MGD MGI:1351606
Rattus norvegicus SYTL4 RGD RGD:620204
Felis catus SYTL4 VGNC VGNC:65907
Bos taurus SYTL4 VGNC VGNC:35548