2. Gene
  3. PIM1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

PIM1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Pim-1 原癌基因，丝氨酸/苏氨酸激酶

种属: Homo sapiens

同用名: PIM

基因 ID: 5292 | 基因类型: protein coding

关于 PIM1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,170,152-37,175,428 (from NCBI)

This gene has 3 transcripts (splice variants), 245 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in bone marrow (RPKM 89.3), esophagus (RPKM 60.8) and 21 other tissues.

功能概要

该基因编码的蛋白质属于 Ser/Thr 蛋白激酶家族和 Pim 亚家族。该基因主要在 B 淋巴细胞系和骨髓细胞系中表达，并在造血系统恶性肿瘤和前列腺癌中过度表达。它在血细胞的信号转导中发挥作用，促进细胞增殖和存活，从而在肿瘤发生中提供选择性优势。据报道，人类和直系同源小鼠基因编码两种亚型 (具有优先细胞定位) ，这是由于使用替代的框内翻译起始密码子，上游非 AUG (CUG) 和下游 AUG 密码子 (PMID：16186805， 1825810) .[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and Pim subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate Cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

PIM1 基因产物(2)

mRNA Protein Name
NM_001243186.2 NP_001230115.1 serine/threonine-protein kinase pim-1 isoform 1
NM_002648.4 NP_002639.1 serine/threonine-protein kinase pim-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
1825810 GOA
enables manganese ion binding IDA
IDA: 通过直接分析推断
1825810 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16186805 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: 通过突变表型推断
16186805 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
1825810 GOA
enables ribosomal small subunit binding IPI
IPI: 通过物理相互作用推断
16266891 GOA
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
18593906 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular detoxification IMP
IMP: 通过突变表型推断
18056989 GOA
involved in cellular response to type II interferon IDA
IDA: 通过直接分析推断
37797010 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
18593906 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
16186805 GOA
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
37797010 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
31548394 GOA
involved in positive regulation of cardiac muscle cell proliferation IDA
IDA: 通过直接分析推断
21474815 GOA
involved in positive regulation of cardioblast proliferation IDA
IDA: 通过直接分析推断
21474815 GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18593906 GOA
involved in positive regulation of protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
16186805 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
16266891 GOA
involved in protein autophosphorylation IMP
IMP: 通过突变表型推断
18593906 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
1825810 GOA
involved in regulation of transmembrane transporter activity IMP
IMP: 通过突变表型推断
18056989 GOA
involved in vitamin D receptor signaling pathway IMP
IMP: 通过突变表型推断
22720752 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
1825810 GOA
located in cytosol IDA
IDA: 通过直接分析推断
16186805 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16186805 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16186805 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIM1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (38 - 290)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase pim-1

Oncogene PIM1

pim-1 oncogene (proviral integration site 1)

proto-oncogene serine/threonine-protein kinase pim-1

关联疾病

疾病名称 别名
Primary Central Nervous System Lymphoma

Pcnsl

Primary Cns Lymphoma

Primary Brain Lymphoma

Primary Lymphoma, Cns

Primary Cerebral Lymphoma
Plasma Protein Metabolism Disease
Dressler'S Syndrome

Dressler Syndrome

Postmyocardial Infarction Syndrome

Donath-Landsteiner Hemolytic Anemia

Post-Myocardial Infarction Syndrome

Postmyocardial Infarction Pericarditis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Polyploidy

Polyploid

Polyploidy Syndrome
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
生物活性分子 (29)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10371 Pim1/AKK1-IN-1 Inhibitor 98.20% 否
HY-N4149 Quercetagetin Inhibitor 99.94% 否
HY-16576A SMI-4a Inhibitor 99.63% 否
HY-16976 GDC-0339 Inhibitor 99.87% 否
HY-101947 SMI-16a Inhibitor ≥98.0% 否
HY-135906 CK2/ERK8-IN-1 Inhibitor ≥99.0% 否
HY-120758 SEL24-B489 Inhibitor 99.02% 否
HY-18086 TCS PIM-1 1 Inhibitor 98.01% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-108605 PIM1-IN-2 Inhibitor ≥99.0% 否
HY-164460 AZD1897 Inhibitor / 否
HY-101870 Uzansertib Inhibitor / 否
HY-149054 GSK-3β inhibitor 13 Inhibitor / 否
HY-168517 PIM-1/CK2-IN-2 Inhibitor / 否
HY-168071 Pim-1 kinase inhibitor 11 Inhibitor / 否
HY-135816 CK2/PIM1-IN-1 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / 否
HY-143897 PIM1-IN-3 Inhibitor / 否
HY-156470 Multi-kinase-IN-6 Inhibitor / 否
HY-147921 PIM1-IN-7 Inhibitor / 否
HY-150731 Pim-1 kinase inhibitor 3 Inhibitor / 否
HY-147920 PIM1-IN-6 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-123983 HS56 Inhibitor / 否
HY-143898 PIM1-IN-4 Inhibitor / 否
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / 否
HY-101783 GNE-955 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PIM1 VGNC VGNC:32899
Rattus norvegicus PIM1 RGD RGD:3330
Felis catus PIM1 VGNC VGNC:102483
Mus musculus PIM1 MGD MGI:97584
Others PIM1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z