Pim-1 kinase inhibitor 9 

Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC₅₀ value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity^[1].

Pim-1 kinase inhibitor 9 抑制乳腺癌细胞 T47D 的生长，IC₅₀值为9.8 μM（48h）和 2.61 μM（96h）^[1]。
Pim-1 kinase inhibitor 9 抑制 Pim-1 kinase 和 Pim-2 kinase 的活性，IC₅₀ 值为 0.24 μM（Pim-1 kinase）和 10.53 μM（Pim-2 kinase）^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pim-1 kinase inhibitors 9（1 mg/kg，每周一次，共三周，腹腔注射）通过促进 caspase-3 的表达和抑制 VEGF 的表达来抑制小鼠Ehrlich实体瘤的生长^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

614.73

C₃₆H₂₄F₂N₄S₂

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Al-Sanea MM,et al., Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166936.  [Content Brief]