1. Gene
  2. ZBTB1 - zinc finger and BTB domain containing 1 Gene

ZBTB1 - zinc finger and BTB domain containing 1 Gene

中文名称:含锌指和 BTB 域 1

种属: Homo sapiens

同用名: ZNF909

基因 ID: 22890 | 基因类型: protein coding

关于 ZBTB1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,503,716-64,533,693 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 14.1), lymph node (RPKM 11.3) and 25 other tissues.

功能概要

启用 K63 连接的多聚泛素修饰依赖性蛋白质结合活性;蛋白质异二聚化活性;和蛋白质同二聚化活性。参与多个过程,包括细胞对紫外线的反应;含核碱基的化合物生物合成过程;和蛋白质同源寡聚化。位于中心体;核体;和核膜。 [由基因组资源联盟提供,2022 年 4 月]

Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including cellular response to UV; nucleobase-containing compound biosynthetic process; and protein homooligomerization. Located in centrosome; nuclear body; and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB1 基因产物(2)

mRNA Protein Name
NM_001123329.2 NP_001116801.1 zinc finger and BTB domain-containing protein 1 isoform 1
NM_014950.3 NP_055765.2 zinc finger and BTB domain-containing protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
24657165 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20211142 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
22753936 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
22753936 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
24657165 GOA
involved in DNA repair IMP
IMP: 通过突变表型推断
24657165 GOA
involved in cellular response to UV IMP
IMP: 通过突变表型推断
24657165 GOA
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
24657165 GOA
involved in mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21706167 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20797634 GOA
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
20797634 GOA
involved in translesion synthesis IMP
IMP: 通过突变表型推断
24657165 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear body IDA
IDA: 通过直接分析推断
20797634 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
20797634 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21706167 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZBTB1 蛋白结构

BTB

BTB: BTB/POZ domain (14 - 115)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (534 - 556)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (592 - 616)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (663 - 684)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (686 - 709)

  • 0
  • 200
  • 400
  • 600
  • 713 a.a.
蛋白主名 其他名称

zinc finger and BTB domain-containing protein 1

ZBTB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZBTB1 Q9Y2K1 PIM1 Homo sapiens P11309
Y2H Array
25416956
种属内
ZBTB1 Q9Y2K1 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
种属内
ZBTB1 Q9Y2K1 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
种属内
ZBTB1 Q9Y2K1 AKR7A2 Homo sapiens O43488
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus ZBTB1 VGNC VGNC:37057
Canis familiaris ZBTB1 VGNC VGNC:48519
Felis catus ZBTB1 VGNC VGNC:67160
Rattus norvegicus ZBTB1 RGD RGD:1303095
Mus musculus ZBTB1 MGD MGI:2442326
Macaca mulatta ZBTB1 VGNC VGNC:79238
Others ZBTB1 NCBI