AKR7A2 - aldo-keto reductase family 7 member A2 Gene

中文名称：醛酮还原酶家族 7 成员 A2

种属: Homo sapiens

同用名: AFAR; AKR7; AFAR1; AFB1-AR1

关于 AKR7A2

功能概要

该基因编码的蛋白属于参与醛酮解毒的醛/酮还原酶 (AKR) 超家族和 AKR7 家族。 AKR7 家族由 3 个基因组成，它们以簇形式存在于 1 号染色体的 p 臂上。这种蛋白质被认为位于高尔基体中，可催化 NADPH 依赖性琥珀半醛还原为内源性神经调节剂 γ-羟基丁酸。它还可以作为解毒酶，减少黄曲霉毒素 B1 和 2-羧基苯甲醛。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication Enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]