1. Gene
  2. AKR7A3 - aldo-keto reductase family 7 member A3 Gene

AKR7A3 - aldo-keto reductase family 7 member A3 Gene

中文名称:醛酮还原酶家族 7 成员 A3

种属: Homo sapiens

同用名: AFAR2

基因 ID: 22977 | 基因类型: protein coding

关于 AKR7A3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,274,229-19,288,770 (from NCBI)

This gene has 1 transcript (splice variant), 490 orthologues and 16 paralogues. Biased expression in duodenum (RPKM 81.0), small intestine (RPKM 50.3) and 6 other tissues.

功能概要

醛酮还原酶,如 AKR7A3,参与醛和酮的解毒。[OMIM 提供,2004 年 4 月]

Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

AKR7A3 基因产物(1)

mRNA Protein Name
NM_012067.3 NP_036199.2 aflatoxin B1 aldehyde reductase member 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AKR7A3 蛋白结构

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (13 - 318)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
蛋白主名 其他名称

aflatoxin B1 aldehyde reductase member 3

AFB1 aldehyde reductase 2

AKR7A3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AKR7A3 O95154 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
AKR7A3 O95154 KRTAP1-1 Homo sapiens Q07627 32296183
种属内
AKR7A3 O95154 AKR7A2 Homo sapiens O43488 33961781
种属内
AKR7A3 O95154 AKR7A2 Homo sapiens O43488 28514442
种属内
AKR7A3 O95154 AKR7A2 Homo sapiens O43488 31515488
种属内
AKR7A3 O95154 AKR7A3 Homo sapiens O95154 32296183
种属内
AKR7A3 O95154 COMMD9 Homo sapiens Q9P000 33961781
种属内
AKR7A3 O95154 AKR7L Homo sapiens Q8NHP1 33961781
种属内
AKR7A3 O95154 AKR7A3 Homo sapiens O95154 16189514
种属内
AKR7A3 O95154 COMMD9 Homo sapiens Q9P000 28514442
种属内
AKR7A3 O95154 AKR7A3 Homo sapiens O95154 32296183
种属内
AKR7A3 O95154 AKR7L Homo sapiens Q8NHP1 28514442
种属内
AKR7A3 O95154 KRT31 Homo sapiens Q15323 32296183
种属内
AKR7A3 O95154 AKR7A3 Homo sapiens O95154 31515488
种属内
AKR7A3 O95154 KRT31 Homo sapiens Q15323 32296183
种属内
AKR7A3 O95154 KRT31 Homo sapiens Q15323 32296183
种属内
AKR7A3 O95154 AKR7A3 Homo sapiens O95154 32296183
种属内
AKR7A3 O95154 AKR7A3 Homo sapiens O95154 25416956
种属内
AKR7A3 O95154 TERF2IP Homo sapiens Q9NYB0 21044950
种属内
AKR7A3 O95154 TERF2IP Homo sapiens Q9NYB0 21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cytochrome P450 Oxidoreductase Deficiency

Por Deficiency

Pord

Antley-Bixler Syndrome With Disordered Steroidogenesis

Antley-Bixler Syndrome

Antley-Bixler Syndrome-Like Phenotype With Disordered Steroidogenesis

Combined Partial Deficiency Of 17-Hydroxylase And 21-Hydroxylase

Congenital Adrenal Hyperplasia Due To Apparent Combined P450c17 And P450c21 Deficiency

Antley-Bixler Syndrome, Autosomal Dominant

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus AKR7A3 MGD MGI:107796
Rattus norvegicus AKR7A3 RGD RGD:628635