2. Gene
  3. POM121 - POM121 transmembrane nucleoporin Gene

POM121 - POM121 transmembrane nucleoporin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：POM121 跨膜核孔蛋白

种属: Homo sapiens

同用名: P145; POM121A

基因 ID: 9883 | 基因类型: protein coding

关于 POM121

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:72,879,357-72,951,459 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues.

功能概要

该基因编码一种跨膜蛋白，定位于内核膜并形成核孔复合体的核心成分，介导进出细胞核的运输。编码的蛋白质可以将该复合物锚定在核膜上。该基因在 5、7、15 和 22 号染色体上有多个相关基因和假基因。已观察到编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

POM121 基因产物(23)

mRNA Protein Name
NM_001257190.3 NP_001244119.1 nuclear envelope pore membrane protein POM 121 isoform 1
NM_001367610.1 NP_001354539.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387685.1 NP_001374614.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387686.1 NP_001374615.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387687.1 NP_001374616.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387688.1 NP_001374617.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387689.1 NP_001374618.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387691.1 NP_001374620.1 nuclear envelope pore membrane protein POM 121 isoform 4
NM_001387692.1 NP_001374621.1 nuclear envelope pore membrane protein POM 121 isoform 5
NM_001387693.1 NP_001374622.1 nuclear envelope pore membrane protein POM 121 isoform 6
NM_001387694.1 NP_001374623.1 nuclear envelope pore membrane protein POM 121 isoform 7
NM_001387695.1 NP_001374624.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387696.1 NP_001374625.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387697.1 NP_001374626.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387698.1 NP_001374627.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387699.1 NP_001374628.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387700.1 NP_001374629.1 nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387701.1 NP_001374630.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387702.1 NP_001374631.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387703.1 NP_001374632.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387704.1 NP_001374633.1 nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387705.1 NP_001374634.1 nuclear envelope pore membrane protein POM 121 isoform 8
NM_172020.5 NP_742017.1 nuclear envelope pore membrane protein POM 121 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear envelope IDA
IDA: 通过直接分析推断
24315095 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POM121 蛋白结构

POM121

POM121: POM121 family (316 - 553)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1249 a.a.
蛋白主名 其他名称

nuclear envelope pore membrane protein POM 121

POM121 membrane glycoprotein

POM121 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra POM121 Q96HA1 PAXIP1 Homo sapiens Q6ZW49-2
Y2H Prey Pooling
25416956
Intra POM121 Q96HA1 AGR2 Homo sapiens O95994
Y2H Pooling
16189514
Intra POM121 Q96HA1 RBPMS Homo sapiens Q93062
Y2H Pooling
16189514
Intra POM121 Q96HA1 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra POM121 Q96HA1 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra POM121 Q96HA1 TEX11 Homo sapiens Q8IYF3
Y2H Pooling
16189514
Intra POM121 Q96HA1 TEX11 Homo sapiens Q8IYF3
Y2H Array
25416956
Intra POM121 Q96HA1 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
25416956
Intra POM121 Q96HA1 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
Intra POM121 Q96HA1 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Dacryocystitis

Dacryocystitis - Acute
Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10864 POM121 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus POM121 MGD MGI:2137624
Rattus norvegicus POM121 RGD RGD:620680
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