CRTC2 - CREB regulated transcription coactivator 2 Gene

中文名称：CREB 调节转录辅激活因子 2

种属: Homo sapiens

同用名: TORC2; TORC-2

关于 CRTC2

功能概要

该基因编码受调节的 cAMP 反应元件结合蛋白活性转录共激活因子家族的转导子成员。这些蛋白质促进 cAMP 反应元件结合蛋白靶向的基因转录，因此在许多细胞过程中发挥重要作用。在基础条件下，编码的蛋白质被 AMP 活化蛋白激酶或盐诱导激酶磷酸化，并被隔离在细胞质中。在被升高的 cAMP 或钙激活后，编码的蛋白质易位到细胞核并增加靶基因表达。该基因中的单核苷酸多态性可能会增加患 2 型糖尿病的风险。该基因的一个假基因位于 5 号染色体的长臂上。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]