2. Gene
  3. NONO - non-POU domain containing octamer binding Gene

NONO - non-POU domain containing octamer binding Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含八聚体结合的非 POU 结构域

种属: Homo sapiens

同用名: P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114

基因 ID: 4841 | 基因类型: protein coding

关于 NONO

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,283,635-71,301,168 (from NCBI)

This gene has 40 transcripts (splice variants), 217 orthologues, 7 paralogues and is associated with 62 phenotypes. Ubiquitous expression in ovary (RPKM 81.7), lymph node (RPKM 64.3) and 25 other tissues.

功能概要

该基因编码一种 RNA 结合蛋白，该蛋白在细胞核中发挥多种作用，包括转录调节和 RNA 剪接。已在乳头状肾细胞癌中观察到该基因与转录因子 E3 基因之间的重排。已经描述了选择性剪接的转录物变体。 2 号和 16 号染色体上存在假基因。[RefSeq 提供，2009 年 2 月]

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

NONO 基因产物(4)

mRNA Protein Name
NM_001145408.2 NP_001138880.1 non-POU domain-containing octamer-binding protein isoform 1
NM_001145409.2 NP_001138881.1 non-POU domain-containing octamer-binding protein isoform 1
NM_001145410.2 NP_001138882.1 non-POU domain-containing octamer-binding protein isoform 2
NM_007363.5 NP_031389.3 non-POU domain-containing octamer-binding protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16148043 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15790595 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
28712728 GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
15790595 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear matrix IDA
IDA: 通过直接分析推断
19874820 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15790595 GOA
is active in paraspeckles IDA
IDA: 通过直接分析推断
19716791 GOA
located in paraspeckles IDA
IDA: 通过直接分析推断
19217333 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NONO 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (76 - 140)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (150 - 210)

NOPS

NOPS: NOPS (NUC059) domain (221 - 272)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
蛋白主名 其他名称

non-POU domain-containing octamer-binding protein

54 kDa nuclear RNA- and DNA-binding protein

NONO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NONO Q15233 C11orf68 Homo sapiens Q9H3H3-3
Validated Y2H
32296183
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1-2
Anti Tag CoIP
28514442
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1-2
Validated Y2H
32296183
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1
Pull Down
16148043
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1
Anti Tag CoIP
33961781
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1
Y2H Array
25416956
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1
Anti Tag CoIP
16148043
Intra NONO Q15233 PSPC1 Homo sapiens Q8WXF1
Y2H Pooling
16169070
Intra NONO Q15233 SFPQ Homo sapiens P23246
Y2H
21988832
Intra NONO Q15233 SFPQ Homo sapiens P23246
Anti Tag CoIP
35271311
Intra NONO Q15233 SFPQ Homo sapiens P23246
Crosslink
30021884
Intra NONO Q15233 SFPQ Homo sapiens P23246
Anti Tag CoIP
28514442
Intra NONO Q15233 SFPQ Homo sapiens P23246
Anti Tag CoIP
33961781
Intra NONO Q15233 FXR1 Homo sapiens P51114
Y2H Pooling
21653829
Intra NONO Q15233 FXR1 Homo sapiens P51114
Anti Tag CoIP
21653829
Intra NONO Q15233 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra NONO Q15233 PIN1 Homo sapiens Q13526
Y2H Pooling
16189514
Intra NONO Q15233 C11orf68 Homo sapiens Q9H3H3
Validated Y2H
25416956
Intra NONO Q15233 C11orf68 Homo sapiens Q9H3H3
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, X-Linked, Syndromic 34

MRXS34

Mental Retardation, X-Linked, Syndromic, Mircsof-Langouet Type

Mrxsml

Mental Retardation, X-Linked, Syndromic 34

Intellectual Developmental Disorder, X-Linked Syndromic 34

Mental Retardation, X-Linked, Syndromic, Type 34
Syndromic X-Linked Intellectual Disability 34

Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome

Mental Retardation, X-Linked, Syndromic 34

Mrxs34

Mrxsml

Syndromic X-Linked Mental Retardation Mircsof-Langouet Type
Renal Cell Carcinoma, Xp11-Associated

RCCX1

Mit Family Translocation Renal Cell Carcinoma

Renal Cell Carcinoma, Papillary, 1

Carcinoma Associated With Mitf/Tfe Translocation

Translocation Renal Cell Carcinoma

Renal Cell Carcinoma Xp11-Associated

Renal Cell Carcinoma Papillary 1

Carcinoma, Renal Cell, Xp11-Associated
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm
Alveolar Soft Part Sarcoma

ASPS

Alveolar Soft-Part Sarcoma

Sarcoma, Alveolar Soft Part

Alveolar Soft Tissue Sarcoma

Sarcoma Alveolar Soft Part

Adult Alveolar Soft-Part Sarcoma

Childhood Alveolar Soft-Part Sarcoma
Perivascular Epithelioid Cell Tumor

Pecoma

Perivascular Epithelioid Cell Neoplasms

Neoplasm With Perivascular Epithelioid Cell Differentiation
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153918 (R)-SKBG-1 Inhibitor 99.50% 否
HY-153918A (S)-SKBG-1 99.01% 否
HY-108960 PPADS Antagonist / 否
HY-RS09425 NONO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NONO VGNC VGNC:75367
Rattus norvegicus NONO RGD RGD:1549738
Mus musculus NONO MGD MGI:1855692
Bos taurus NONO VGNC VGNC:32163
Canis familiaris NONO VGNC VGNC:54178
Others NONO NCBI
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