2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. PPADS

PPADS 是一种 P2 受体 拮抗剂，IC50 分别为 68 nM (P2X1) 和 214 nM (P2X3)。PPADS 可作为 ATP (核苷酸) 模拟物，与 ATP 竞争 P2 受体上的结合位点。PPADS 还是 NAADP 受体 的可逆竞争性拮抗剂。PPADS 可逆转痛觉过敏，并降低神经系统外周和中枢步骤中增加的 NO/NOS 信号传导和 IL-1β产生。

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PPADS Chemical Structure

PPADS Chemical Structure

CAS No. : 149017-66-3

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PPADS 的其他形式现货产品:

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Other Forms of PPADS:

PPADS 相关抗体

Top Publications Citing Use of Products

查看 P2X Receptor 亚型特异性产品:

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P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].

IC50 & Target[2]

p2x1 Receptor

68 nM (IC50)

P2X2 Receptor

214 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Oocyte IC50
0.099 μM
Compound: 1
Inhibition of inward ion current elicited by ATP at P2X1 receptor expressed in Xenopus oocytes
Inhibition of inward ion current elicited by ATP at P2X1 receptor expressed in Xenopus oocytes
[PMID: 11462975]
Oocyte IC50
0.24 μM
Compound: 1
Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytes
Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytes
[PMID: 11462975]
Oocyte IC50
1.6 μM
Compound: 1
Inhibition of inward ion current elicited by ATP at P2X2 receptor expressed in Xenopus oocytes
Inhibition of inward ion current elicited by ATP at P2X2 receptor expressed in Xenopus oocytes
[PMID: 11462975]
分子量

511.38

Formula

C14H14N3O12PS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPADS 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPADS149017-66-3P2X ReceptorP2XRsnociceptiveATP mimeticInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-108960
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