PSPC1 - paraspeckle component 1 Gene

中文名称：副啄木鸟成分 1

种属: Homo sapiens

同用名: PSP1

关于 PSPC1

功能概要

该基因编码一种核仁蛋白，该蛋白定位于靠近剪接斑点 (称为副啄木鸟) 的点状亚核结构。这些副啄木鸟由 RNA 蛋白质结构组成，包括非编码 RNA、NEAT1/Men epsilon/beta 和果蝇行为人类剪接蛋白家族，其中包括该基因的产物以及 P54NRB/NONO 和 PSF/SFPQ 蛋白质。副啄木鸟可能通过 RNA 核保留机制控制基因表达。由该基因编码的蛋白质存在于转录活跃细胞的副啄木鸟中，但当 RNA 聚合酶 II 转录受到抑制或处于末期时，它定位于核仁外围的独特帽状结构。该基因的可变剪接导致多个转录变体。已经确定了一个相关的假基因，它也位于 13 号染色体上。[RefSeq 提供，2011 年 8 月]

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]