PFKFB4 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Gene

中文名称：6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 4

种属: Homo sapiens

关于 PFKFB4

功能概要

该基因编码的蛋白质是四种双功能激酶/磷酸酶之一，可调节糖酵解副产物果糖-2,6-二磷酸 (F2,6BP) 的浓度。编码的蛋白质在癌细胞中高表达，并由缺氧诱导。这种蛋白质对于癌细胞在缺氧条件下的存活至关重要，因为它会在细胞无法产生大量 F2、6BP 和 ATP 时增加它们的数量。这一发现表明，这种蛋白质可能是破坏癌细胞的良好靶标，有望危及它们的生存。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in Cancer cells and is induced by hypoxia. This protein is essential to the survival of Cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in Cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]