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  2. APOL1 - apolipoprotein L1 Gene

APOL1 - apolipoprotein L1 Gene

中文名称:载脂蛋白 L1

种属: Homo sapiens

同用名: APOL; APO-L; FSGS4; APOL-I

基因 ID: 8542 | 基因类型: protein coding

关于 APOL1

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,253,133-36,267,525 (from NCBI)

This gene has 10 transcripts (splice variants), 509 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 56.2), urinary bladder (RPKM 39.7) and 21 other tissues.

功能概要

该基因编码与载脂蛋白 AI 结合的分泌型高密度脂蛋白。载脂蛋白 AI 是一种相对丰富的血浆蛋白,是 HDL 的主要载脂蛋白。它参与血浆中大多数胆固醇酯的形成,还促进胆固醇从细胞中流出。这种载脂蛋白 L 家族成员可能在脂质交换和全身转运以及胆固醇从外周细胞到肝脏的反向转运中发挥作用。已发现该基因的几种不同的转录变体编码不同的亚型。[RefSeq 提供,2008 年 11 月]

This gene encodes a secreted high density lipoprotein which binds to Apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of Cholesterol from cells. This Apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse Cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

APOL1 基因产物(5)

mRNA Protein Name
NM_001136540.2 NP_001130012.1 apolipoprotein L1 isoform a precursor
NM_001136541.2 NP_001130013.1 apolipoprotein L1 isoform c
NM_001362927.2 NP_001349856.1 apolipoprotein L1 isoform c
NM_003661.4 NP_003652.2 apolipoprotein L1 isoform a precursor
NM_145343.3 NP_663318.1 apolipoprotein L1 isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chloride channel activity IDA
IDA: 通过直接分析推断
16020735 GOA
enables lipid binding IDA
IDA: 通过直接分析推断
16020735 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12621437 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chloride transmembrane transport IDA
IDA: 通过直接分析推断
16020735 GOA
involved in cytolysis by host of symbiont cells IDA
IDA: 通过直接分析推断
12621437 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
17192540 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
17192540 GOA
part of high-density lipoprotein particle IDA
IDA: 通过直接分析推断
9325276 GOA
part of very-low-density lipoprotein particle IDA
IDA: 通过直接分析推断
17154273 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

APOL1 蛋白结构

ApoL

ApoL: Apolipoprotein L (79 - 392)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

apolipoprotein L1

apolipoprotein L 1

APOL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
APOL1 O14791 CDC23 Homo sapiens Q9UJX2
Validated Y2H
25416956
种属内
APOL1 O14791 CDC23 Homo sapiens Q9UJX2
Y2H Prey Pooling
25416956
种属内
APOL1 O14791 FAM20C Homo sapiens Q8IXL6
Protein Kinase Assay
22582013
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 APOL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75504 Apolipoprotein L/APOL1 Protein, Human (sf9, His) Q2KHQ6 (E28-L398) ≥95%

APOL1 抗体

目录号 产品名 应用 反应物种
HY-P82148 ApoL1 Antibody (YA1893) WB, ICC/IF, IP, FC Human

关联疾病

疾病名称 别名
Focal Segmental Glomerulosclerosis 4

Focal Segmental Glomerulosclerosis 4, Susceptibility To

FSGS4

Glomerulosclerosis, Focal Segmental, 4, Susceptibility To

Glomerulosclerosis, Focal Segmental, 4

Glomerulosclerosis, Segmental, Focal, Type 4, Susceptibility To

Glomerulonephritis

Bright'S Disease

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis

Trypanosomiasis
End Stage Renal Disease

End Stage Renal Failure

End-Stage Kidney Disease

Kidney Failure, Chronic

Chronic Kidney Disease Stage 5

Phencyclidine Abuse

Pcp Abuse

Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Genetic Srns

Hereditary Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Nephrotic Syndrome

Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive

Srn1

Focal Segmental Glomerulosclerosis 5

FSGS5

Glomerulosclerosis, Focal Segmental, 5

Glomerulosclerosis, Segmental, Focal, Type 5

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis

Orthostatic Proteinuria

Postural Albuminuria

Plasmodium Malariae Malaria

Quartan Malaria

Malaria By Plasmodium Malariae

Nephrotic Syndrome Of Quartan Malaria

Malaria Nephrosis

Malarial Nephrosis

Nephrotic Syndrome In Malaria

Quartan Nephrosis

Oligomeganephronia

Oligomeganephronic Renal Hypoplasia

Oligomeganephronic Hypoplasia Of Kidney

Kidney Papillary Necrosis

Necrotizing Renal Papillitis

Papillary Necrosis

Renal Papillitis Necrotizing

Renal Artery Disease

Renal Vascular Disease

Vascular Disorder Of Kidney

Renal Vascular Disorder

Lipoid Nephrosis

Minimal Change Disease

Minimal Change Glomerulonephritis

Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis

Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome

Idiopathic Minimal Change Nephrotic Syndrome

Mcns

Minimal Change Glomerulopathy

Minimal Change Nephrotic Syndrome

Nephrotic Syndrome Minimal Change

Nephrosis, Lipoid

Glomerulonephritis, Minimal Change

Nephrotic Syndrome, Minimal Change

Renal Hypertension

Hypertension Renal

Hypertension, Renal

Acute Kidney Tubular Necrosis

Acute Tubular Necrosis

Acute Renal Failure With Tubular Necrosis

Acute Tubule Necrosis

Acute Renal Failure With Lesion Of Tubular Necrosis

Atn - Acute Tubular Necrosis

Tubular Necrosis Acute

Kidney Tubular Necrosis, Acute

Acute Renal Tubular Necrosis

Acute Tubular Nephrosis

Ischaemic Acute Tubular Necrosis

Ischaemic Tubular Necrosis

Kidney Tubular Necrosis

Lower Nephron Nephrosis

Necrotising Renal Oedema

Renal Tubular Necrosis

Toxic Tubular Necrosis

Tubular Kidney Necrosis

Tubular Necrosis Nos

Tubular Nephrosis

Alport Syndrome

Hereditary Nephritis

Alport Syndrome, X-Linked

Hemorrhagic Hereditary Nephritis

Congenital Hereditary Hematuria

Hemorrhagic Familial Nephritis

Familial Nephritis

Thin Basement Membrane Disease

Thin Basement Membrane Nephropathy

Hematuria-Nephropathy-Deafness Syndrome

Hematuric Hereditary Nephritis

Hereditary Familial Congenital Hemorrhagic Nephritis

Hereditary Hematuria Syndrome

Hereditary Interstitial Pyelonephritis

Alport Deafness-Nephropathy

Alport Hearing Loss-Nephropathy

Alports Syndrome

Nephritis, Hereditary

Parasitic Protozoa Infectious Disease

Protozoan Infections

Mastigophora Infectious Disease

Sarcomastigophora Infectious Disease

Interstitial Nephritis

Nephritis, Interstitial

Renal Tubulo-Interstitial Disease

Nephritis Interstitial

Nephritis, Tubulointerstitial

Sickle Cell Anemia

Hemoglobin Sc Disease

Anemia, Sickle Cell

Hbsc Disease

Sickle Cell-Hemoglobin C Disease Syndrome

Hb Ss Disease

Sickle Cell Trait

Drepanocytosis

Haemoglobin Sc Disease

Hb Sc Disease

Hb-S/Hb-C Disease

Hb-Ss Disease Without Crisis

Hemoglobin S Disease Without Crisis

Sickle Cell Anaemia

Sickle-Cell/Hb-C Disease Without Crisis

Sickle Cell - Hemoglobin C Disease

Hbs Disease

Hemoglobin S Disease

Sickling Disorder Due To Hemoglobin S

SKCA

Sickle Cell Disease

Sickle Cell-Hemoglobin C Disease

Sickle-Cell Disease Carrier

Sickle-Cell Heterozygous Disorder

Haemoglobin A-S Genotype

Hb-S - [Sickle Cell Haemoglobin] Carrier

Sickle Cell Haemoglobin Trait

As - [Sickle Cell Trait]

Hbas - [Sickle Cell Haemoglobin Trait]

Sickle-Cell Trait Haemoglobin Disease

Haemoglobin Sickle Cell Trait Disorder

Heterozygous Sickle Cell Trait

Hbas - [Heterozygous Haemoglobin S]

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis

Dense Deposit Disease

Membranoproliferative Glomerulonephritis Type 2

Primary Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis, Type Ii

Glomerulonephritis, Membranoproliferative

Chronic Glomerulonephritis, Lobular

Lobular Glomerulonephritis

Ddd

Glomerulonephritis Membranoproliferative Type 2

Mpgn 2

Membranoproliferative Glomerulonephritis Type Ii

Mesangiocapillary Glomerulonephritis Type 2

Mpgn

Primary Mpgn

Glomerulonephritis Membranoproliferative

Membranoproliferative Glomerulonephritis, Type Ii

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1

Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus APOL1 NCBI