RTKN - rhotekin Gene

中文名称：罗特金

种属: Homo sapiens

关于 RTKN

功能概要

该基因编码与 GTP 结合的 Rho 蛋白相互作用的支架蛋白。该蛋白的结合会抑制 Rho 蛋白的 GTPase 活性。这种蛋白质可能会干扰 RhoGAP 将活性 GTP 结合 Rho 转化为非活性 GDP 结合形式。 Rho 蛋白调节许多重要的细胞过程，包括胞质分裂、转录、平滑肌收缩、细胞生长和转化。 Rho 信号转导通路的失调与多种癌症有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]