Rhoa - ras homolog family member A Gene

种属: Mus musculus

同用名: Arha; Arha1; Arha2

基因 ID: 11848 | 基因类型: protein coding

关于 Rhoa

功能概要

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Rhoa 基因产物(3)

mRNA	Protein	Name
NM_001313961.1	NP_001300890.1	transforming protein RhoA precursor
NM_001313962.1	NP_001300891.1	transforming protein RhoA precursor
NM_016802.5	NP_058082.2	transforming protein RhoA precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activity	IDA IDA: 通过直接分析推断	10699171	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9214622	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Rho protein signal transduction	IMP IMP: 通过突变表型推断	22019888	MGI
acts upstream of or within actin cytoskeleton organization	IDA IDA: 通过直接分析推断	1643657	MGI
involved in alpha-beta T cell lineage commitment	IMP IMP: 通过突变表型推断	25398325	MGI
acts upstream of or within androgen receptor signaling pathway	IDA IDA: 通过直接分析推断	16254014	MGI
acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IMP IMP: 通过突变表型推断	24335996	MGI
involved in apical junction assembly	IDA IDA: 通过直接分析推断	20974804	MGI
involved in beta selection	IMP IMP: 通过突变表型推断	25398325	MGI
involved in bone trabecula morphogenesis	IMP IMP: 通过突变表型推断	22019888	MGI
acts upstream of or within cell adhesion	IMP IMP: 通过突变表型推断	14657280	MGI
acts upstream of or within cell differentiation	IDA IDA: 通过直接分析推断	11877460	MGI
acts upstream of or within cell morphogenesis	IGI IGI: 通过遗传相互作用推断	15860730	MGI
acts upstream of or within cell-matrix adhesion	IDA IDA: 通过直接分析推断	1643657	MGI
acts upstream of or within cerebral cortex cell migration	IMP IMP: 通过突变表型推断	22405202	MGI
acts upstream of or within cytoskeleton organization	IMP IMP: 通过突变表型推断	22405202	MGI
acts upstream of or within forebrain radial glial cell differentiation	IMP IMP: 通过突变表型推断	22405202	MGI
acts upstream of or within kidney development	IGI IGI: 通过遗传相互作用推断	25071083	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: 通过突变表型推断	15071095	MGI
involved in negative regulation of cell-substrate adhesion	IMP IMP: 通过突变表型推断	18981818	MGI
acts upstream of or within negative regulation of intracellular steroid hormone receptor signaling pathway	IDA IDA: 通过直接分析推断	16254014	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IMP IMP: 通过突变表型推断	15071095	MGI
involved in negative regulation of oxidative phosphorylation	IMP IMP: 通过突变表型推断	25398325	MGI
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: 通过突变表型推断	25398325	MGI
acts upstream of or within neuron migration	IMP IMP: 通过突变表型推断	22405202	MGI
involved in odontogenesis	IEP IEP: 通过表达模式推断	25911094	MGI
involved in ossification involved in bone maturation	IMP IMP: 通过突变表型推断	22019888	MGI
involved in positive regulation of alpha-beta T cell differentiation	IMP IMP: 通过突变表型推断	25398325	MGI
acts upstream of or within positive regulation of podosome assembly	IGI IGI: 通过遗传相互作用推断	21525037	MGI
acts upstream of or within positive regulation of stress fiber assembly	IDA IDA: 通过直接分析推断	25071083	MGI
acts upstream of or within positive regulation of vascular associated smooth muscle contraction	IMP IMP: 通过突变表型推断	24335996	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	25398325	MGI
involved in regulation of microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	25398325	MGI
acts upstream of or within regulation of neural precursor cell proliferation	IMP IMP: 通过突变表型推断	22405202	MGI
acts upstream of or within regulation of neuron projection development	IDA IDA: 通过直接分析推断	21976490	MGI
involved in regulation of osteoblast proliferation	IMP IMP: 通过突变表型推断	22019888	MGI
acts upstream of or within regulation of systemic arterial blood pressure by endothelin	IMP IMP: 通过突变表型推断	24335996	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18332105	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: 通过突变表型推断	22019888	MGI
acts upstream of or within skeletal muscle tissue development	IDA IDA: 通过直接分析推断	11877460	MGI
acts upstream of or within stress fiber assembly	IDA IDA: 通过直接分析推断	10699171	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	11877460	MGI
located in lamellipodium	IDA IDA: 通过直接分析推断	18824598	MGI
located in nucleus	IDA IDA: 通过直接分析推断	15093731	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	15093731	MGI
located in ruffle membrane	IDA IDA: 通过直接分析推断	9214622	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transforming protein RhoA

aplysia ras-related homolog A

ras homolog gene family, member A

Rhoa 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Rhoa	Q9QUI0	Rtkn	Mus musculus	Q8C6B2	Pull Down	21029865

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	纯度	是否罕见病
HY-10341	Fasudil Hydrochloride	99.96%	是
HY-109523	Cerivastatin sodium	99.89%	否
HY-10341A	Fasudil	/	否
HY-10341B	Fasudil hydrochloride semihydrate	/	否
HY-10341C	Fasudil dihydrochloride	/	否

目录号	产品名	作用方式	纯度	Phase
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12646	Rhosin hydrochloride		99.93%	否
HY-16563	Narciclasine	Activator	99.88%	否
HY-108566	U-46619	Agonist	≥99.0%	否
HY-15477	YS-49		99.92%	否
HY-108361	CCG-203971	Inhibitor	≥98.0%	否
HY-12649	Y16	Inhibitor	98.10%	否
HY-113849	MLS-573151	Inhibitor	99.74%	否
HY-115376	Z62954982	Inhibitor	≥99.0%	否
HY-145915A	(E/Z)-ZINC09659342	Inhibitor	99.72%	否
HY-15477A	YS-49 monohydrate		99.71%	否
HY-109523S	Cerivastatin-d3 sodium		/	否
HY-129458	Cerivastatin		/	否
HY-139061	Palmitoyl 3-carbacyclic phosphatidic acid	Inhibitor	/	否
HY-145915	ZINC09659342	Inhibitor	/	否
HY-162968	MRTF-A-IN-1	Inhibitor	/	否
HY-162969	MRTF-A-IN-2	Inhibitor	/	否
HY-168596	RhoA-ROCK-IN-1		/	否
HY-P2325	Exoenzyme C3, clostridium botulinum		/	否
HY-RS11945	RHOA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-10341D	Fasudil mesylate		/	否
HY-121667	Scaff10-8	Inhibitor	/	否
HY-12646A	Rhosin		/	否
HY-158652	(R)-CCG-1423	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Rhoa	NCBI	NCBI:387

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Rhoa - ras homolog family member A Gene

关于 Rhoa

功能概要

Rhoa 基因产物(3)

Rhoa 蛋白互作信息

直系同源

热门区域

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Rhoa - ras homolog family member A Gene

关于 Rhoa

功能概要

Rhoa 基因产物(3)

Rhoa 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z