2. Gene
  3. MSI1 - musashi RNA binding protein 1 Gene

MSI1 - musashi RNA binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：武藏 RNA 结合蛋白 1

种属: Homo sapiens

基因 ID: 4440 | 基因类型: protein coding

关于 MSI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,339,662-120,369,164 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues.

功能概要

该基因编码的蛋白质含有两个保守的串联 RNA 识别基序。其他物种中的类似蛋白质起 RNA 结合蛋白的作用，并在转录后基因调控中发挥核心作用。该基因的表达与神经胶质瘤和黑色素瘤的恶性程度和增殖活性相关。该基因的假基因位于染色体 11q13。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in Other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

MSI1 基因产物(15)

mRNA Protein Name
NM_001414485.1 NP_001401414.1 RNA-binding protein Musashi homolog 1 isoform b
NM_001414486.1 NP_001401415.1 RNA-binding protein Musashi homolog 1 isoform c
NM_001414487.1 NP_001401416.1 RNA-binding protein Musashi homolog 1 isoform d
NM_001414488.1 NP_001401417.1 RNA-binding protein Musashi homolog 1 isoform e
NM_001414489.1 NP_001401418.1 RNA-binding protein Musashi homolog 1 isoform f
NM_001414490.1 NP_001401419.1 RNA-binding protein Musashi homolog 1 isoform g
NM_001414491.1 NP_001401420.1 RNA-binding protein Musashi homolog 1 isoform h
NM_001414492.1 NP_001401421.1 RNA-binding protein Musashi homolog 1 isoform i
NM_001414493.1 NP_001401422.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414494.1 NP_001401423.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414495.1 NP_001401424.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414496.1 NP_001401425.1 RNA-binding protein Musashi homolog 1 isoform k
NM_001414497.1 NP_001401426.1 RNA-binding protein Musashi homolog 1 isoform l
NM_001414498.1 NP_001401427.1 RNA-binding protein Musashi homolog 1 isoform l
NM_002442.4 NP_002433.1 RNA-binding protein Musashi homolog 1 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
30367664 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30367664 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MSI1 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (23 - 90)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (111 - 177)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

RNA-binding protein Musashi homolog 1

musashi-1

MSI1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MSI1 O43347 HNRNPH2 Homo sapiens P55795
Validated Y2H
32296183
种属内
MSI1 O43347 HNRNPF Homo sapiens P52597
Validated Y2H
32296183
种属内
MSI1 O43347 MSI1 Homo sapiens O43347
Comigration in SDS
30367664
种属内
MSI1 O43347 MSI1 Homo sapiens O43347
AFM
30367664
种属间: 跨种属相互作用 种属内: 同种属相互作用

MSI1 抗体

目录号 产品名 应用 反应物种
HY-P83070 Musashi 1 Antibody (YA2815) WB, IHC-P, ICC/IF, IP, FC Human

关联疾病

疾病名称 别名
Omsk Hemorrhagic Fever

Ohf

Hemorrhagic Fever, Omsk

Ohf - [Omsk Haemorrhagic Fever]

Spring-Fall Haemorrhagic Fever
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119734 Gossypolone 96.63% 否
HY-RS08714 MSI1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MSI1 VGNC VGNC:68325
Bos taurus MSI1 VGNC VGNC:31697
Macaca mulatta MSI1 VGNC VGNC:74935
Rattus norvegicus MSI1 RGD RGD:628778
Mus musculus MSI1 MGD MGI:107376
Canis familiaris MSI1 VGNC VGNC:43442
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