HNRNPH2 - heterogeneous nuclear ribonucleoprotein H2 Gene

中文名称：异质核核糖核蛋白 H2

种属: Homo sapiens

同用名: FTP3; MRXSB; NRPH2; HNRPH'; HNRPH2; hnRNPH'

基因 ID: 3188 | 基因类型: protein coding

关于 HNRNPH2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:101,408,222-101,414,133 (from NCBI)

This gene has 1 transcript (splice variant), 130 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 50.7), adrenal (RPKM 42.7) and 25 other tissues.

功能概要

该基因属于普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族。 hnRNPs 是 RNA 结合蛋白，它们与异质核 RNA (hnRNA) 复合。这些蛋白质与细胞核中的前体 mRNA 相关，并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。虽然所有的 hnRNPs 都存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。由该基因编码的蛋白质具有三个重复的与 RNA 结合的准 RRM 结构域。它与家族成员 HNRPH1 非常相似。该基因被认为与法布雷病和 X 连锁无丙种球蛋白血症表型有关。可变剪接导致编码相同蛋白质的多个转录变体。已观察到该基因座与核糖体蛋白 L36a 基因之间的通读转录。[RefSeq 提供，2011 年 1 月]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011]

HNRNPH2 基因产物(2)

mRNA	Protein	Name
NM_001032393.3	NP_001027565.1	heterogeneous nuclear ribonucleoprotein H2
NM_019597.5	NP_062543.1	heterogeneous nuclear ribonucleoprotein H2

HNRNPH2 蛋白结构

zf-RNPHF

0
100
200
300
400
449 a.a.

蛋白主名

其他名称

heterogeneous nuclear ribonucleoprotein H2

FTP-3

HNRNPH2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Array	32296183
种属内	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	25416956
种属内	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	32296183
种属内	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Validated Y2H	32296183
种属内	HNRNPH2	P55795	TEKT1	Homo sapiens	Q969V4	Y2H Array	25416956
种属内	HNRNPH2	P55795	CCNK	Homo sapiens	O75909-2	Y2H Array	32296183
种属内	HNRNPH2	P55795	CCNK	Homo sapiens	O75909-2	Y2H Prey Pooling	32296183
种属内	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Y2H Prey Pooling	32296183
种属内	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Validated Y2H	25416956
种属内	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Validated Y2H	32296183
种属内	HNRNPH2	P55795	MSI2	Homo sapiens	Q96DH6	Y2H Array	32296183
种属内	HNRNPH2	P55795	PLOD1	Homo sapiens	Q02809	Anti Tag CoIP	28514442
种属内	HNRNPH2	P55795	PLOD1	Homo sapiens	Q02809	Anti Tag CoIP	26496610
种属内	HNRNPH2	P55795	PLOD1	Homo sapiens	Q02809	Anti Tag CoIP	33961781
种属内	HNRNPH2	P55795	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
种属内	HNRNPH2	P55795	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
种属内	HNRNPH2	P55795	MSI1	Homo sapiens	O43347	Y2H Prey Pooling	32296183
种属内	HNRNPH2	P55795	MSI1	Homo sapiens	O43347	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type

MRXSB	Mental Retardation, X-Linked, Syndromic, Bain Type
Intellectual Developmental Disorder, X-Linked Syndromic, Bain Type

Bain Type Of X-Linked Syndromic Intellectual Disability

Intellectual Disability, X-Linked, Syndromic, Bain Type

Hnrnph2 Deficiency

Motor Stereotypies

Motor Stereotypy

Stereotypic Movement Disorder

Stereotypy Habit Disorder	Stereotyped Repetitive Movements
Stereotyped Disorder	Stereotypes Nos
Stereotype Habit Disorder

Syndromic X-Linked Intellectual Disability 94

Mrx94	Mrxs29
Syndromic X-Linked Intellectual Disability Due To Gria3 Anomalies	Syndromic X-Linked Mental Retardation 29
Syndromic X-Linked Mental Retardation Wu Type

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Myotonic Disease

Myotonic Disorders	Myotonic Syndrome
Symptomatic Myotonia

Deafness, Autosomal Recessive 109

DFNB109	Autosomal Recessive Nonsyndromic Deafness 109
Autosomal Recessive Deafness 109	Deafness, Autosomal Recessive, 109

Myotonic Dystrophy 2

Myotonic Dystrophy Type 2	Proximal Myotonic Myopathy
Promm	Ricker Syndrome
DM2	Dystrophia Myotonica 2
Myotonic Myopathy, Proximal	Myotonic Disorders
Dystrophia Myotonica Type 2	Proximal Myotonic Dystrophy
Ricker Disease	Myotonic Dystrophy, Type 2
Dystrophy, Myotonic, Type 2

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Myotonic Dystrophy 1

Myotonic Dystrophy	Dystrophia Myotonica
Steinert Disease	Myotonic Dystrophy Type 1
Myotonia Atrophica	DM1
Congenital Myotonic Dystrophy	Myotonia Dystrophica
Steinert Myotonic Dystrophy	Dystrophia Myotonica 1
Dm	Steinert'S Disease
Steinert Myotonic Dystrophy Syndrome	Myotonic Dystrophy Of Steinert
Dystrophia Myotonica Type 1	Myotonic Dystrophy Congenital
Dystrophy, Myotonic, Type 1	Dm - [Dystrophia Myotonica]
Myotonic Muscular Dystrophy

Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8	SCA8
Ataxia, Spinocerebellar, Type 8

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Congenital Myasthenic Syndrome

Congenital Myasthenia	Congenital Myasthenic Syndromes
Cms	Myasthenic Syndromes, Congenital
Myasthenic Syndromes Congenital	Myasthenic Syndrome, Congenital
Congenital Myasthenic Syndrome Ib	Congenital And Developmental Myasthenia
Developmental Myasthenia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06271	HNRNPH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	HNRNPH2	VGNC	VGNC:67608
Bos taurus	HNRNPH2	VGNC	VGNC:50192
Rattus norvegicus	HNRNPH2	RGD	RGD:1549784
Canis familiaris	HNRNPH2	VGNC	VGNC:41731
Mus musculus	HNRNPH2	MGD	MGI:1201779
Macaca mulatta	HNRNPH2	VGNC	VGNC:110582

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HNRNPH2 - heterogeneous nuclear ribonucleoprotein H2 Gene

关于 HNRNPH2

功能概要

HNRNPH2 基因产物(2)

HNRNPH2 蛋白结构

HNRNPH2 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

HNRNPH2 - heterogeneous nuclear ribonucleoprotein H2 Gene

关于 HNRNPH2

功能概要

HNRNPH2 基因产物(2)

HNRNPH2 蛋白结构

HNRNPH2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z