2. Gene
  3. MSI2 - musashi RNA binding protein 2 Gene

MSI2 - musashi RNA binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：武藏 RNA 结合蛋白 2

种属: Homo sapiens

同用名: MSI2H

基因 ID: 124540 | 基因类型: protein coding

关于 MSI2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:57,255,851-57,701,581 (from NCBI)

This gene has 31 transcripts (splice variants), 261 orthologues, 36 paralogues and is associated with 66 phenotypes. Ubiquitous expression in adrenal (RPKM 11.7), ovary (RPKM 7.0) and 24 other tissues.

功能概要

该基因编码的 RNA 结合蛋白是 Musashi 蛋白家族的一员。编码的蛋白质是转录调节因子，其靶向参与发育和细胞周期调节的基因。该基因的突变与某些类型癌症的不良预后有关。该基因也被证明在某些癌细胞中发生了重排。[RefSeq 提供，2016 年 4 月]

This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain Cancer cells. [provided by RefSeq, Apr 2016]

MSI2 基因产物(4)

mRNA Protein Name
NM_001322250.2 NP_001309179.1 RNA-binding protein Musashi homolog 2 isoform c
NM_001322251.2 NP_001309180.1 RNA-binding protein Musashi homolog 2 isoform d
NM_138962.4 NP_620412.1 RNA-binding protein Musashi homolog 2 isoform a
NM_170721.2 NP_733839.1 RNA-binding protein Musashi homolog 2 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
30367664 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MSI2 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (24 - 91)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (112 - 178)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
蛋白主名 其他名称

RNA-binding protein Musashi homolog 2

musashi homolog 2

MSI2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MSI2 Q96DH6 CACNA1C Homo sapiens Q13936
Anti Bait CoIP
37207277
种属内
MSI2 Q96DH6 TIMM10B Homo sapiens Q9Y5J6
Anti Tag CoIP
33961781
种属内
MSI2 Q96DH6 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属内
MSI2 Q96DH6 MSI2 Homo sapiens Q96DH6
AFM
30367664
种属内
MSI2 Q96DH6 MEOX2 Homo sapiens P50222
Y2H Array
25416956
种属内
MSI2 Q96DH6 HNRNPH2 Homo sapiens P55795
Y2H Prey Pooling
25416956
种属内
MSI2 Q96DH6 MSI2 Homo sapiens Q96DH6
Comigration in SDS
30367664
种属内
MSI2 Q96DH6 MSI2 Homo sapiens Q96DH6
Confocal
30367664
种属内
MSI2 Q96DH6 MSI2 Homo sapiens Q96DH6
IF
30367664
种属内
MSI2 Q96DH6 HNRNPH2 Homo sapiens P55795
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

MSI2 抗体

目录号 产品名 应用 反应物种
HY-P83300 Musashi 2 Antibody (YA3045) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Pineal Region Germinoma

Pineal Germinoma
B-Cell Adult Acute Lymphocytic Leukemia

Adult B Acute Lymphoblastic Leukemia

Adult B Acute Lymphoblastic Leukaemia

Adult B-Cell Acute Lymphoblastic Leukaemia

Adult B-Cell Acute Lymphoblastic Leukemia

Adult B-Cell Lymphocytic Leukaemia

Adult B-Cell Lymphocytic Leukemia

Adult B-Lymphoblastic Leukaemia

Adult B-Lymphoblastic Leukemia

B-Cell Adult Acute Lymphocytic Leukaemia

B-Cell Adult Acute Lymphoblastic Leukemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08715 MSI2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MSI2 MGD MGI:1923876
Rattus norvegicus MSI2 RGD RGD:1560397
Macaca mulatta MSI2 VGNC VGNC:74793
Bos taurus MSI2 VGNC VGNC:107272
Others MSI2 NCBI
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