1. Gene
  2. DZIP1L - DAZ interacting zinc finger protein 1 like Gene

DZIP1L - DAZ interacting zinc finger protein 1 like Gene

中文名称:DAZ 相互作用锌指蛋白 1 样

种属: Homo sapiens

同用名: PKD5; DZIP2

基因 ID: 199221 | 基因类型: protein coding

关于 DZIP1L

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,061,990-138,115,608 (from NCBI)

This gene has 9 transcripts (splice variants), 142 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in stomach (RPKM 1.1), skin (RPKM 1.0) and 24 other tissues.

功能概要

预测可启用金属离子结合活性。参与纤毛组装和蛋白质定位的调节。位于睫状体基部。与中心粒共定位。与多囊肾病有关 5。[由基因组资源联盟提供,2022 年 4 月]

Predicted to enable metal ion binding activity. Involved in cilium assembly and regulation of protein localization. Located in ciliary basal body. Colocalizes with centriole. Implicated in polycystic kidney disease 5. [provided by Alliance of Genome Resources, Apr 2022]

DZIP1L 基因产物(2)

mRNA Protein Name
NM_001170538.1 NP_001164009.1 cilium assembly protein DZIP1L isoform 2
NM_173543.3 NP_775814.2 cilium assembly protein DZIP1L isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cilium assembly IMP
IMP: 通过突变表型推断
19852954 GOA
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
28530676 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with centriole IDA
IDA: 通过直接分析推断
19852954 GOA
located in centriole IDA
IDA: 通过直接分析推断
28530676 GOA
located in ciliary basal body IDA
IDA: 通过直接分析推断
19852954 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DZIP1L 蛋白结构

Dzip-like_N

Dzip-like_N: Iguana/Dzip1-like DAZ-interacting protein N-terminal (24 - 144)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
蛋白主名 其他名称

cilium assembly protein DZIP1L

DAZ interacting protein 1-like

DZIP1L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DZIP1L Q8IYY4 PNMA5 Homo sapiens Q96PV4
Y2H Array
32296183
Intra DZIP1L Q8IYY4 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
32296183
Intra DZIP1L Q8IYY4 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra DZIP1L Q8IYY4 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra DZIP1L Q8IYY4 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra DZIP1L Q8IYY4 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra DZIP1L Q8IYY4 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
27107012
Intra DZIP1L Q8IYY4 CBY2 Homo sapiens Q8NA61-2
BFG-2H
27107012
Intra DZIP1L Q8IYY4 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra DZIP1L Q8IYY4 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra DZIP1L Q8IYY4 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra DZIP1L Q8IYY4 TRIM37 Homo sapiens O94972
Y2H Prey Pooling
32296183
Intra DZIP1L Q8IYY4 TRIM37 Homo sapiens O94972
Y2H Array
32296183
Intra DZIP1L Q8IYY4 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra DZIP1L Q8IYY4 CEP76 Homo sapiens Q8TAP6
Y2H Array
25416956
Intra DZIP1L Q8IYY4 LRRN4 Homo sapiens Q8WUT4
Validated Y2H
32296183
Intra DZIP1L Q8IYY4 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra DZIP1L Q8IYY4 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra DZIP1L Q8IYY4 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra DZIP1L Q8IYY4 CBY1 Homo sapiens Q9Y3M2
Y2H Prey Pooling
32296183
Intra DZIP1L Q8IYY4 CBY1 Homo sapiens Q9Y3M2
Validated Y2H
32296183
Intra DZIP1L Q8IYY4 CBY1 Homo sapiens Q9Y3M2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polycystic Kidney Disease 5

PKD5

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease

Arpkd

Polycystic Kidney Disease, Autosomal Recessive

Polycystic Kidney And Hepatic Disease 1

Pkhd1

PKD4

Polycystic Kidney Disease 4 With Or Without Hepatic Disease

Polycystic Kidney Disease, Infantile, Type I

Polycystic Kidney Disease, Infantile Type

Polycystic Kidney, Autosomal Recessive

Pkd3, Formerly

Polycystic Kidney Disease 4, With Or Without Hepatic Disease

Arpkd/Chf

Ar-Pkd

Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease

Infantile Polycystic Kidney Disease Type I

Pkd3

Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease

Polycystic Kidney Disease 3, Autosomal Dominant

Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

Kidney Disease

Renal Failure

Kidney Failure

Kidney Diseases

Nephropathy

Abnormality Of The Kidney

Impaired Renal Function Disease

Renal Anomaly

Kidney Dysfunction

Renal Disease

Nephropathies

Renal Failure Adverse Event

Abnormal Renal Function

Congenital Anomalies Of Kidney And Urinary Tract 1

CAKUT1

Renal Hypodysplasia, Nonsyndromic, 1

Rhdns1

Congenital Anomalies Of The Kidney And Urinary Tract 1

Non-Syndromic Renal Hypodysplasia 1

Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1

Diabetes Insipidus, Nephrogenic, 2, Autosomal

Diabetes Insipidus, Nephrogenic, Autosomal

NDI2

Diabetes Insipidus, Nephrogenic, Type Ii

Diabetes Insipidus, Nephrogenic, 2

Nephrogenic Diabetes Insipidus Type 2

Autosomal Nephrogenic Diabetes Insipidus-2

Diabetes Insipidus, Nephrogenic Type 2

ANDI

Diabetes Insipidus Nephrogenic Type 2

Doid:0081061

Nephrogenic Diabetes Insipidus

Congenital Nephrogenic Diabetes Insipidus

Adh-Resistant Diabetes Insipidus

Renal Dysplasia, Cystic

CYSRD

Renal Dysplasia, Cystic, Susceptibility To

Diffuse Cystic Renal Dysplasia

Renal Dysplasia Diffuse Cystic

Cystic Renal Dysplasia

Susceptibility To Cystic Renal Dysplasia

Dysplasia, Renal, Cystic, Susceptibility To

Multicystic Dysplastic Kidney

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2

CGD2

Ncf2 Deficiency

P67-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii

Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii

Granulomatous Disease, Chronic, Due To Ncf2 Deficiency

Neutrophil Cytosol Factor 2 Deficiency

Chronic Granulomatous Disease 2, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 2

Cdg2

Deficiency Of Ncf2

Deficiency Of P67-Phox

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii

Deficiency Of Neutrophil Cytosol Factor 2

Avellino Corneal Dystrophy

End Stage Renal Disease

End Stage Renal Failure

End-Stage Kidney Disease

Kidney Failure, Chronic

Chronic Kidney Disease Stage 5

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease

Isolated Polycystic Liver Disease

Pcld

Congenital Cystic Liver Disease

Congenital Hepatic Cyst

Fibrocystic Liver Disease

Isolated Autosomal Dominant Polycystic Liver Disease

Adpcld

Liver Disease, Polycystic

Multiple Cysts Of Liver

Pld - [Polycystic Liver Disease]

Polycystic Liver Disorder

Polycystic Liver

Congenital Polycystic Disease Of Liver

Congenital Polycystic Liver Disease

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]

Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst

Oligohydramnios

Oligohydramnios - Delivered

Antepartum Oligohydramnios

Delivered Oligohydramnios

Oligohydramnios, Antepartum Condition Or Complication

Deficient Liquor

Oligohydramnios, Unspecified Trimester

Reduced Liquor Volume

Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary

Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DZIP1L MGD MGI:1919757
Rattus norvegicus DZIP1L RGD RGD:1311430
Felis catus DZIP1L VGNC VGNC:61692
Canis familiaris DZIP1L VGNC VGNC:40162
Macaca mulatta DZIP1L VGNC VGNC:71910
Bos taurus DZIP1L VGNC VGNC:53540