CBY1 - chibby family member 1, beta catenin antagonist Gene

中文名称：chibby 家族成员 1，β 连环蛋白拮抗因子

种属: Homo sapiens

同用名: CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A

基因 ID: 25776 | 基因类型: protein coding

关于 CBY1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,656,638-38,673,850 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues.

功能概要

β-连环蛋白是一种转录激活剂和癌蛋白，参与多种癌症的发展。由该基因编码的蛋白质直接与 β-连环蛋白的 C 末端区域相互作用，通过与转录因子竞争结合 β-连环蛋白来抑制致癌的 β-连环蛋白介导的转录激活。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CBY1 基因产物(2)

mRNA	Protein	Name
NM_001002880.4	NP_001002880.3	protein chibby homolog 1
NM_015373.4	NP_056188.1	protein chibby homolog 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables beta-catenin binding	IDA IDA: 通过直接分析推断	12712206	GOA
enables beta-catenin binding	IPI IPI: 通过物理相互作用推断	16424001	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	15194699	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15194699	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	21182262	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12712206	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: 通过直接分析推断	12712206	GOA
involved in protein homotetramerization	IDA IDA: 通过直接分析推断	21182262	GOA
involved in protein localization	IMP IMP: 通过突变表型推断	15194699	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centriole	IDA IDA: 通过直接分析推断	22911743	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12712206	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	15194699	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBY1 蛋白结构

Chibby

0
100
126 a.a.

蛋白主名

其他名称

protein chibby homolog 1

ARPP-binding protein

CBY1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CBY1	Q9Y3M2	TTC23L	Homo sapiens	Q6PF05-3	Y2H Array	25416956
种属内	CBY1	Q9Y3M2	DZIP1L	Homo sapiens	Q8IYY4	Anti Tag CoIP	33961781
种属内	CBY1	Q9Y3M2	CIBAR1	Homo sapiens	A1XBS5	Anti Tag CoIP	33961781
种属内	CBY1	Q9Y3M2	CIBAR1	Homo sapiens	A1XBS5	Y2H Prey Pooling	25416956
种属内	CBY1	Q9Y3M2	CIBAR1	Homo sapiens	A1XBS5	Y2H Array	25416956
种属内	CBY1	Q9Y3M2	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
种属内	CBY1	Q9Y3M2	YWHAZ	Homo sapiens	P63104	CoIP	18573912
种属内	CBY1	Q9Y3M2	YWHAE	Homo sapiens	P62258	TAP	27173435
种属内	CBY1	Q9Y3M2	YWHAE	Homo sapiens	P62258	CoIP	18573912
种属内	CBY1	Q9Y3M2	CFAP53	Homo sapiens	Q96M91	Lumier	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Ulcerative Blepharitis

Macular Degeneration, Age-Related, 9

Age Related Macular Degeneration 9	ARMD9
Macular Degeneration, Age-Related, 9, Susceptibility To	Macular Degeneration, Age-Related, Type 9

Granulomatous Orchitis

Non-Specific Granulomatous Orchitis

Myringitis Bullosa Hemorrhagica

Bullous Myringitis

Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14	ARMD14
Macular Degeneration, Age-Related, 14, Reduced Risk Of	Macular Degeneration, Age-Related, Type 14

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02016	CBY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CBY1	VGNC	VGNC:26822
Mus musculus	CBY1	MGD	MGI:1920989
Felis catus	CBY1	VGNC	VGNC:60427
Canis familiaris	CBY1	VGNC	VGNC:38770
Macaca mulatta	CBY1	VGNC	VGNC:107103
Rattus norvegicus	CBY1	RGD	RGD:708481

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